139427-42-2|S-Nitrosohomocysteine|S-nitroso-L-homocysteine|-范德生物科技公司

S-Nitrosohomocysteine

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names：
S-nitroso-L-homocysteine
CAS号：
139427-42-2
MDL Number：
MF(分子式)： C4H8N2O3S MW(分子量)： 164.17
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	S-nitroso-L-homocysteine
英文别名	S-Nitrosohomocysteine;
CAS号	139427-42-2
SMILES	N[C@@H](CCSN=O)C(O)=O
Inchi	InChI=1S/C4H8N2O3S/c5-3(4(7)8)1-2-10-6-9/h3H,1-2,5H2,(H,7,8)/t3-/m0/s1
InchiKey	QWPCKAAAWDCDCW-VKHMYHEASA-N
分子式 Formula	C4H8N2O3S
分子量 Molecular Weight	164.17
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	S-Nitrosohomocysteine(CAS:139427-42-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	S-Nitrosohomocysteine is a DDAH Inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Karver CE, Ahmed VF, Barrios AM. Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):285-7. doi: 10.1016/j.bmcl.2010.11.025. Epub 2010 Nov 9. PubMed PMID: 21129966.

[2]Morakinyo MK, Strongin RM, Simoyi RH. Modulation of homocysteine toxicity by S-nitrosothiol formation: a mechanistic approach. J Phys Chem B. 2010 Aug 5;114(30):9894-904. doi: 10.1021/jp103679v. PubMed PMID: 20666529.

[3] Hong L, Fast W. Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia. J Biol Chem. 2007 Nov 30;282(48):34684-92. Epub 2007 Sep 24. PubMed PMID: 17895252.

[4] Chobanyan K, Thum T, Suchy MT, Zhu B, Mitschke A, Gutzki FM, Beckmann B, Stichtenoth DO, Tsikas D. GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 15;858(1-2):32-41. Epub 2007 Aug 7. PubMed PMID: 17825631.

[5] Braun O, Knipp M, Chesnov S, Vasák M. Specific reactions of S-nitrosothiols with cysteine hydrolases: A comparative study between dimethylargininase-1 and CTP synthetase. Protein Sci. 2007 Aug;16(8):1522-34. Epub 2007 Jun 28. PubMed PMID: 17600152; PubMed Central PMCID: PMC2203367.

6: Broniowska KA, Zhang Y, Hogg N. Requirement of transmembrane transport for S-nitrosocysteine-dependent modification of intracellular thiols. J Biol Chem. 2006 Nov 10;281(45):33835-41. Epub 2006 Aug 7. PubMed PMID: 16893892; PubMed Central PMCID: PMC1839924.7: Frey D, Braun O, Briand C, Vasák M, Grütter MG. Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors. Structure. 2006 May;14(5):901-11. PubMed PMID: 16698551.8: Zhang Y, Hogg N. S-Nitrosothiols: cellular formation and transport. Free Radic Biol Med. 2005 Apr 1;38(7):831-8. Review. PubMed PMID: 15749378.9: Knipp M, Braun O, Vasák M. Searching for DDAH inhibitors: S-nitroso-L-homocysteine is a chemical lead. J Am Chem Soc. 2005 Mar 2;127(8):2372-3. PubMed PMID: 15724974.10: Lee SJ, Kim KM, Namkoong S, Kim CK, Kang YC, Lee H, Ha KS, Han JA, Chung HT, Kwon YG, Kim YM. Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. J Biol Chem. 2005 Feb 18;280(7):5781-8. Epub 2004 Nov 23. PubMed PMID: 15561702.1

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