139689-10-4|SKF-77434, (S)-|(S)-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol|-范德生物科技公司

SKF-77434, (S)-

NMR下载 COA and HPLC MSDS下载
names：
(S)-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
CAS号：
139689-10-4
MDL Number：
MF(分子式)： C19H21NO2 MW(分子量)： 295.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
英文别名	SKF-77434, (S)-; S-(-)-SKF-77434; J482.833J; S-(-)-Apd;
CAS号	139689-10-4
Inchi	InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2/t17-/m0/s1
InchiKey	QBUVZVXIRYFENV-KRWDZBQOSA-N
分子式 Formula	C19H21NO2
分子量 Molecular Weight	295.38
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SKF-77434, (S)-(CAS:139689-10-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Cauli O, Morelli M. Subchronic caffeine administration sensitizes rats to the motor-activating effects of dopamine D(1) and D(2) receptor agonists. Psychopharmacology (Berl). 2002 Jul;162(3):246-54. Epub 2002 May 14. PubMed PMID: 12122482.

[2]Mutschler NH, Bergman J. Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys. Psychopharmacology (Berl). 2002 Apr;160(4):362-70. Epub 2002 Feb 12. PubMed PMID: 11919663.

[3] Schindler CW, Gilman JP, Bergman J, Mello NK, Woosley RL, Goldberg SR. Interactions between cocaine and dopamine agonists on cardiovascular function in squirrel monkeys. J Pharmacol Exp Ther. 2002 Jan;300(1):180-7. PubMed PMID: 11752114.

[4] Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology (Berl). 2001 Sep;157(2):208-16. PubMed PMID: 11594448.

[5] Caine SB, Negus SS, Mello NK, Bergman J. Effects of dopamine D1-like and D2-like agonists in rats trained to discriminate cocaine from saline: influence of experimental history. Exp Clin Psychopharmacol. 2000 Aug;8(3):404-14. PubMed PMID: 10975632.

6: Platt DM, Rowlett JK, Spealman RD. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J Pharmacol Exp Ther. 2000 Jun;293(3):1017-26. PubMed PMID: 10869406.7: Caine SB, Negus SS, Mello NK, Bergman J. Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine. J Pharmacol Exp Ther. 1999 Oct;291(1):353-60. PubMed PMID: 10490924.8: Katz JL, Kopajtic TA, Myers KA, Mitkus RJ, Chider M. Behavioral effects of cocaine: interactions with D1 dopaminergic antagonists and agonists in mice and squirrel monkeys. J Pharmacol Exp Ther. 1999 Oct;291(1):265-79. PubMed PMID: 10490913.9: Tidey JW, Bergman J. Drug discrimination in methamphetamine-trained monkeys: agonist and antagonist effects of dopaminergic drugs. J Pharmacol Exp Ther. 1998 Jun;285(3):1163-74. PubMed PMID: 9618419.10: Abrahams BS, Rutherford JD, Mallet PE, Beninger RJ. Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434. Eur J Pharmacol. 1998 Feb 19;343(2-3):111-8. PubMed PMID: 9570457.1

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