122271-41-4|Shermilamine B|Acetamide, N-(2-(8,11,12,13-tetrahydro-12-oxopyrido(4,3,2-mn)(1,4)thiazino(3,2-b)acridin-9-yl)ethyl)-|-范德生物科技公司

Shermilamine B

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names：
Acetamide, N-(2-(8,11,12,13-tetrahydro-12-oxopyrido(4,3,2-mn)(1,4)thiazino(3,2-b)acridin-9-yl)ethyl)-
CAS号：
122271-41-4
MDL Number：
MF(分子式)： C21H18N4O2S MW(分子量)： 390.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Acetamide, N-(2-(8,11,12,13-tetrahydro-12-oxopyrido(4,3,2-mn)(1,4)thiazino(3,2-b)acridin-9-yl)ethyl)-
英文别名	Shermilamine B; Debromoshermilamine A.
CAS号	122271-41-4
Inchi	InChI=1S/C21H18N4O2S/c1-11(26)22-8-7-14-18-17-13(12-4-2-3-5-15(12)24-18)6-9-23-19(17)20-21(14)28-10-16(27)25-20/h2-6,9,24H,7-8,10H2,1H3,(H,22,26)(H,25,27)
InchiKey	IHFPKDUIXNIBMM-UHFFFAOYSA-N
分子式 Formula	C21H18N4O2S
分子量 Molecular Weight	390.46
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Shermilamine B(CAS:122271-41-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Shermilamine B is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bontemps N, Gattacceca F, Long C, Thomas OP, Banaigs B. Additional cytotoxic pyridoacridine alkaloids from the ascidian Cystodytes violatinctus and biogenetic considerations. J Nat Prod. 2013 Sep 27;76(9):1801-5. doi: 10.1021/np400284z. Epub 2013 Aug 20. PubMed PMID: 23961991.

[2]Bontemps N, Bry D, López-Legentil S, Simon-Levert A, Long C, Banaigs B. Structures and antimicrobial activities of pyridoacridine alkaloids isolated from different chromotypes of the ascidian Cystodytes dellechiajei. J Nat Prod. 2010 Jun 25;73(6):1044-8. doi: 10.1021/np900751k. PubMed PMID: 20491501.

[3] López-Legentil S, Bontemps-Subielos N, Turon X, Banaigs B. Temporal variation in the production of four secondary metabolites in a colonial ascidian. J Chem Ecol. 2006 Sep;32(9):2079-84. Epub 2006 Aug 5. PubMed PMID: 16924427.

[4] Townsend NO, Jackson YA. Synthesis of 9-methyl-1H-[1,4]thiazino[3,2-g]quinoline-2,5,10(3H)-trione, the B,C,D ring core of the shermilamine alkaloids. Org Biomol Chem. 2003 Oct 21;1(20):3557-63. PubMed PMID: 14599017.

[5] Delfourne E, Bastide J. Marine pyridoacridine alkaloids and synthetic analogues as antitumor agents. Med Res Rev. 2003 Mar;23(2):234-52. Review. PubMed PMID: 12500290.

6: Koren-Goldshlager G, Aknin M, Kashman Y. Cycloshermilamine D, a new pyridoacridine from the marine tunicate cystodytes violatinctus. J Nat Prod. 2000 Jun;63(6):830-1. PubMed PMID: 10869211.7: McDonald LA, Eldredge GS, Barrows LR, Ireland CM. Inhibition of topoisomerase II catalytic activity by pyridoacridine alkaloids from a Cystodytes sp. ascidian: a mechanism for the apparent intercalator-induced inhibition of topoisomerase II. J Med Chem. 1994 Oct 28;37(22):3819-27. PubMed PMID: 7525959.

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