123924-38-9|Sekdel sequence|(2S,5S,8S,11S,14S)-14-((S)-2-amino-3-hydroxypropanamido)-11-(4-aminobutyl)-5-(2-carboxyethyl)-8-(carboxymethyl)-2-isobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecanedioic acid|-范德生物科技公司

Sekdel sequence

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names：
(2S,5S,8S,11S,14S)-14-((S)-2-amino-3-hydroxypropanamido)-11-(4-aminobutyl)-5-(2-carboxyethyl)-8-(carboxymethyl)-2-isobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecanedioic acid
CAS号：
123924-38-9
MDL Number：
MF(分子式)： C29H49N7O14 MW(分子量)： 719.74
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(2S,5S,8S,11S,14S)-14-((S)-2-amino-3-hydroxypropanamido)-11-(4-aminobutyl)-5-(2-carboxyethyl)-8-(carboxymethyl)-2-isobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecanedioic acid
英文别名	Sekdel sequence; Ser-glu-lys-asp-glu-leu; Seryl-glutamyl-lysyl-aspartyl-glutamyl-leucine;
CAS号	123924-38-9
Inchi	InChI=1S/C29H49N7O14/c1-14(2)11-20(29(49)50)36-27(47)18(7-9-22(40)41)34-28(48)19(12-23(42)43)35-25(45)16(5-3-4-10-30)33-26(46)17(6-8-21(38)39)32-24(44)15(31)13-37/h14-20,37H,3-13,30-31H2,1-2H3,(H,32,44)(H,33,46)(H,34,48)(H,35,45)(H,36,47)(H,38,39)(H,40,41)(H,42,43)(H,49,50)/t15-,16-,17-,18-,19-,20-/m0/s1
InchiKey	BKWMKTIGFLPGOV-RABCQHRBSA-N
分子式 Formula	C29H49N7O14
分子量 Molecular Weight	719.74
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sekdel sequence(CAS:123924-38-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sekdel sequence is a signal which leads to retention of at least two proteins in the endoplasmic reticulum of animal cells.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Biocca S, Tafani M, Cattaneo A. Assembled IgG molecules are exported from the endoplasmic reticulum in myeloma cells despite the retention signal SEKDEL. Biochem Biophys Res Commun. 1998 May 19;246(2):518-23. PubMed PMID: 9610394.

[2]Zagouras P, Rose JK. Carboxy-terminal SEKDEL sequences retard but do not retain two secretory proteins in the endoplasmic reticulum. J Cell Biol. 1989 Dec;109(6 Pt 1):2633-40. PubMed PMID: 2592401; PubMed Central PMCID: PMC2115906.

[3] zu Putlitz J, Skerra A, Wands JR. Intracellular expression of a cloned antibody fragment interferes with hepatitis B virus surface antigen secretion. Biochem Biophys Res Commun. 1999 Feb 24;255(3):785-91. PubMed PMID: 10049788.

[4] Kim YS, Kim MY, Kim TG, Yang MS. Expression and assembly of cholera toxin B subunit (CTB) in transgenic carrot (Daucus carota L.). Mol Biotechnol. 2009 Jan;41(1):8-14. doi: 10.1007/s12033-008-9086-z. Epub 2008 Jul 19. PubMed PMID: 18642102.

[5] Haq TA, Mason HS, Clements JD, Arntzen CJ. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science. 1995 May 5;268(5211):714-6. PubMed PMID: 7732379.

6: Tabe LM, Higgins CM, McNabb WC, Higgins TJ. Genetic engineering of grain and pasture legumes for improved nutritive value. Genetica. 1993;90(2-3):181-200. Review. PubMed PMID: 8119592.7: Chong DK, Langridge WH. Expression of full-length bioactive antimicrobial human lactoferrin in potato plants. Transgenic Res. 2000 Feb;9(1):71-8. PubMed PMID: 10853271.

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