117796-52-8|SCH-37370|1-(4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidin-1-yl)ethan-1-one|-范德生物科技公司

SCH-37370

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names：
1-(4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidin-1-yl)ethan-1-one
CAS号：
117796-52-8
MDL Number：
MF(分子式)： C21H21ClN2O MW(分子量)： 352.862
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	1-(4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidin-1-yl)ethan-1-one
英文别名	SCH-37370; SCH 37370; SCH37370.
CAS号	117796-52-8
Inchi
InchiKey
分子式 Formula	C21H21ClN2O
分子量 Molecular Weight	352.862
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SCH-37370(CAS:117796-52-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SCH-37370 is a potent, orally active, dual antagonist of platelet-activating factor and histamine. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 = 0.6 microM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 = 1.2 microM). Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes.
Application1
Application2
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危险性	Warning
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备注

[1]Kaminski JJ, Carruthers NI, Wong SC, Chan TM, Billah MM, Tozzi S, McPhail AT. Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorg Med Chem. 1999 Jul;7(7):1413-23. PubMed PMID: 10465415.

[2]Centemeri C, Colli S, Tosarello D, Ciceri P, Nicosia S. Heterogeneous platelet-activating factor (PAF) receptors and calcium increase in platelets and macrophages. Biochem Pharmacol. 1999 Feb 1;57(3):263-71. PubMed PMID: 9890553.

[3] Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010.

[4] Balsa D, Merlos M, Giral M, Ferrando R, García-Rafanell J, Forn J. Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method. J Pharmacol Toxicol Methods. 1996 Sep;36(1):53-62. PubMed PMID: 8872920.

[5] Billah MM, Gilchrest HG, Eckel SP, Granzow CA, Lawton PJ, Radwanski E, Brannan MD, Affrime MB, Christopher JD, Richards W, et al. Differential plasma duration of antiplatelet-activating factor and antihistamine activities of oral Sch 37370 in humans. Clin Pharmacol Ther. 1992 Aug;52(2):151-9. PubMed PMID: 1505150.

6: Billah MM, Egan RW, Ganguly AK, Green MJ, Kreutner W, Piwinski JJ, Siegel MI, Villani FJ, Wong JK. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4. PubMed PMID: 1819703.7: Billah MM, Chapman RW, Watnick AS, Egan RW, Siegel MI, Kreutner W. Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine. Agents Actions Suppl. 1991;3

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