53527-28-9|Scalaradial|(4aS,4bR,6S,6aS,7R,10aS,10bR,12aS)-7,8-diformyl-1,1,4a,6a,10b-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,10,10a,10b,11,12,12a-hexadecahydrochrysen-6-yl acetate|-范德生物科技公司

Scalaradial

NMR下载 COA and HPLC MSDS下载
names：
(4aS,4bR,6S,6aS,7R,10aS,10bR,12aS)-7,8-diformyl-1,1,4a,6a,10b-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,10,10a,10b,11,12,12a-hexadecahydrochrysen-6-yl acetate
CAS号：
53527-28-9
MDL Number：
MF(分子式)： C27H40O4 MW(分子量)： 428.61
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(4aS,4bR,6S,6aS,7R,10aS,10bR,12aS)-7,8-diformyl-1,1,4a,6a,10b-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,10,10a,10b,11,12,12a-hexadecahydrochrysen-6-yl acetate
英文别名	Scalaradial;
CAS号	53527-28-9
SMILES	CC(O[C@H]1C[C@@H]2[C@]3(CCCC(C)([C@@H]3CC[C@]2([C@@H]4CC=C([C@@H]([C@@]14C)C=O)C=O)C)C)C)=O
Inchi	InChI=1S/C27H40O4/c1-17(30)31-23-14-22-25(4)12-7-11-24(2,3)20(25)10-13-26(22,5)21-9-8-18(15-28)19(16-29)27(21,23)6/h8,15-16,19-23H,7,9-14H2,1-6H3/t19-,20-,21-,22+,23-,25-,26-,27+/m0/s1
InchiKey	ADWFEADZGIHPDE-QGERINELSA-N
分子式 Formula	C27H40O4
分子量 Molecular Weight	428.61
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Scalaradial(CAS:53527-28-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Scalaradial is a marine sesterterpenoid isolated from the sponge Cacospongia mollior with anti-inflammatory effects.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Cassiano C, Margarucci L, Esposito R, Riccio R, Tosco A, Casapullo A, Monti MC. In cell scalaradial interactome profiling using a bio-orthogonal clickable probe. Chem Commun (Camb). 2014 Jun 7;50(45):6043-5. doi: 10.1039/c4cc00989d. Epub 2014 Apr 28. PubMed PMID: 24769547.

[2]De Stefano D, Tommonaro G, Malik SA, Iodice C, De Rosa S, Maiuri MC, Carnuccio R. Cacospongionolide and scalaradial, two marine sesterterpenoids as potent apoptosis-inducing factors in human carcinoma cell lines. PLoS One. 2012;7(4):e33031. doi: 10.1371/journal.pone.0033031. Epub 2012 Apr 3. PubMed PMID: 22509253; PubMed Central PMCID: PMC3317917.

[3] Margarucci L, Monti MC, Chini MG, Tosco A, Riccio R, Bifulco G, Casapullo A. The inactivation mechanism of human group IIA phospholipase A(2) by Scalaradial. Chembiochem. 2012 Oct 15;13(15):2259-64. doi: 10.1002/cbic.201200453. Epub 2012 Sep 24. PubMed PMID: 23008213.

[4] Torregrosa G, Pérez-Asensio FJ, Burguete MC, Castelló-Ruiz M, Salom JB, Alborch E. Chronic intracerebroventricular delivery of the secretory phospholipase A2 inhibitor, 12-epi-scalaradial, does not improve outcome after focal cerebral ischemia-reperfusion in rats. Exp Brain Res. 2007 Jan;176(2):248-59. PubMed PMID: 16874515.

[5] Monti MC, Casapullo A, Cavasotto CN, Napolitano A, Riccio R. Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation. Chembiochem. 2007 Sep 3;8(13):1585-91. PubMed PMID: 17691073.

6: de Carvalho MS, Jacobs RS. Two-step inactivation of bee venom phospholipase A2 by scalaradial. Biochem Pharmacol. 1991 Sep 27;42(8):1621-6. PubMed PMID: 1930288.7: Marshall LA, Winkler JD, Griswold DE, Bolognese B, Roshak A, Sung CM, Webb EF, Jacobs R. Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation. J Pharmacol Exp Ther. 1994 Feb;268(2):709-17. PubMed PMID: 8113982.8: Barnette MS, Rush J, Marshall LA, Foley JJ, Schmidt DB, Sarau HM. Effects of scalaradial, a novel inhibitor of 14 kDa phospholipase A2, on human neutrophil function. Biochem Pharmacol. 1994 Apr 29;47(9):1661-7. PubMed PMID: 8185681.9: Monti MC, Casapullo A, Riccio R, Gomez-Paloma L. The inactivation of phospholipase A2 by scalaradial: a biomimetic study by electrospray mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(3):303-8. PubMed PMID: 15645482.10: Xie Y, Yu Z, Liu L, Guo Y, Lou L. Biphasic regulation of extracellular signal-regulated kinases by scalaradial, a secretory phospholipase A(2) inhibitor. Cancer Biol Ther. 2006 Aug;5(8):988-92. Epub 2006 Aug 3. PubMed PMID: 16760675.1

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