205678-26-8|SB-267268|2-[(4S)-3-Oxo-8-[3-(pyridin-2-ylamino)propoxy]-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-benzazepin-4-yl]acetic acid|-范德生物科技公司

SB-267268

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names：
2-[(4S)-3-Oxo-8-[3-(pyridin-2-ylamino)propoxy]-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-benzazepin-4-yl]acetic acid
CAS号：
205678-26-8
MDL Number：
MF(分子式)： C22H24F3N3O4 MW(分子量)： 451.4462
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2-[(4S)-3-Oxo-8-[3-(pyridin-2-ylamino)propoxy]-2-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-2-benzazepin-4-yl]acetic acid
英文别名	SB-267268; SB 267268; SB267268.
CAS号	205678-26-8
Inchi	InChI=1S/C22H24F3N3O4/c23-22(24,25)14-28-13-17-11-18(32-9-3-8-27-19-4-1-2-7-26-19)6-5-15(17)10-16(21(28)31)12-20(29)30/h1-2,4-7,11,16H,3,8-10,12-14H2,(H,26,27)(H,29,30)/t16-/m0/s1
InchiKey	PVDGZHKJXXVONO-INIZCTEOSA-N
分子式 Formula	C22H24F3N3O4
分子量 Molecular Weight	451.4462
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SB-267268(CAS:205678-26-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SB-267268 is a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. SB-267268 reduced pathologic angiogenesis in ROP mice by approximately 50% and had no effect on developmental retinal angiogenesis in shams. Both VEGF and VEGFR-2 mRNA were upregulated in the inner retina of ROP mice and reduced with SB-267268. Nonpeptidic inhibition of alpha(v)beta3 and alpha(v)beta5 integrins is effective in ROP and may be a suitable anti-angiogenic therapy for other ischemic retinal pathologies.
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wilkinson-Berka JL, Jones D, Taylor G, Jaworski K, Kelly DJ, Ludbrook SB,Willette RN, Kumar S, Gilbert RE. SB-267268, a nonpeptidic antagonist ofalpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGFexpression in a mouse model of retinopathy of prematurity. Invest Ophthalmol VisSci. 2006 Apr;47(4):1600-5. PubMed PMID: 16565398.