157659-79-5|SB-209670|(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid|-范德生物科技公司

SB-209670

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names：
(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid
CAS号：
157659-79-5
MDL Number：
MF(分子式)： C29H28O9 MW(分子量)： 520.534
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid
英文别名	SB-209670; SB 209670; SB209670.
CAS号	157659-79-5
SMILES	O=C([C@@H]1[C@@H](C2=CC=C(OCO3)C3=C2)C4=C(C=C(OCCC)C=C4)[C@H]1C5=CC=C(C=C5OCC(O)=O)OC)O
Inchi	InChI=1S/C29H28O9/c1-3-10-35-18-6-7-19-21(12-18)27(20-8-5-17(34-2)13-23(20)36-14-25(30)31)28(29(32)33)26(19)16-4-9-22-24(11-16)38-15-37-22/h4-9,11-13,26-28H,3,10,14-15H2,1-2H3,(H,30,31)(H,32,33)/t26-,27+,28+/m0/s1
InchiKey	UUAVCCWBNUITBB-UPRLRBBYSA-N
分子式 Formula	C29H28O9
分子量 Molecular Weight	520.534
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SB-209670(CAS:157659-79-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SB-209670 is a endothelin receptor antagonist. SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog. SB 209670 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B)-receptor activity in the rat. (last updated 6/18/2016).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Burrell KM, Molenaar P, Dawson PJ, Kaumann AJ. Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: blockade with SB 209670. J Pharmacol Exp Ther. 2000 Jan;292(1):449-59. PubMed PMID: 10604982.

[2]Bunting MW, Widdop RE. Differential haemodynamic effects of endothelin receptor antagonist, SB 209670, in conscious hypertensive and normotensive rats. Eur J Pharmacol. 1999 Sep 17;381(1):13-21. PubMed PMID: 10528129.

[3] Freed MI, Wilson DE, Thompson KA, Harris RZ, Ilson BE, Jorkasky DK. Pharmacokinetics and pharmacodynamics of SB 209670, an endothelin receptor antagonist: effects on the regulation of renal vascular tone. Clin Pharmacol Ther. 1999 May;65(5):473-82. PubMed PMID: 10340912.

[4] Schroeder RL, Keiser JA, Cheng XM, Haleen SJ. PD 142893, SB 209670, and BQ 788 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B)-receptor activity in the rat. J Cardiovasc Pharmacol. 1998 Dec;32(6):935-43. PubMed PMID: 9869499.

[5] Douglas SA, Nichols AJ, Feuerstein GZ, Elliott JD, Ohlstein EH. SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog. J Cardiovasc Pharmacol. 1998;31 Suppl [5]S99-102. PubMed PMID: 9595411.

6: Ishikawa A, Suzuki K, Fujita K. Effect of the endothelin receptor antagonist, SB 209670 on cyclosporine-induced nephrotoxicity. Transplant Proc. 1998 Feb;30(1):40-2. PubMed PMID: 9474951.7: Hay DW, Luttmann MA. Nonpeptide endothelin receptor antagonists. IX. Characterization of endothelin receptors in guinea pig bronchus with SB 209670 and other endothelin receptor antagonists. J Pharmacol Exp Ther. 1997 Feb;280(2):959-65. PubMed PMID: 9023312.8: Gardiner SM, Kemp PA, March JE, Bennett T. Influence of aminoguanidine and the endothelin antagonist, SB 209670, on the regional haemodynamic effects of endotoxaemia in conscious rats. Br J Pharmacol. 1996 Aug;118(7):1822-8. PubMed PMID: 8842449; PubMed Central PMCID: PMC1909836.9: Nambi P, Pullen M, Wu HL, Lee D, Saunders D, Heys R, Aiyar N, Leber J, Elliott J, Brooks D, Ohlstein E, Ruffolo R. Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors. J Pharmacol Exp Ther. 1996 Jun;277(3):1567-71. PubMed PMID: 8667224.10: Ruetten H, Thiemermann C, Vane JR. Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. Br J Pharmacol. 1996 May;118(1):198-204. PubMed PMID: 8733596; PubMed Central PMCID: PMC1909477.1

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