157659-79-5|SB-209670|(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid|-范德生物科技公司

SB-209670

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names：
(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid
CAS号：
157659-79-5
MDL Number：
MF(分子式)： C29H28O9 MW(分子量)： 520.534
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid
英文别名	SB-209670; SB 209670; SB209670.
CAS号	157659-79-5
Inchi	InChI=1S/C29H28O9/c1-3-10-35-18-6-7-19-21(12-18)27(20-8-5-17(34-2)13-23(20)36-14-25(30)31)28(29(32)33)26(19)16-4-9-22-24(11-16)38-15-37-22/h4-9,11-13,26-28H,3,10,14-15H2,1-2H3,(H,30,31)(H,32,33)/t26-,27+,28+/m0/s1
InchiKey	UUAVCCWBNUITBB-UPRLRBBYSA-N
分子式 Formula	C29H28O9
分子量 Molecular Weight	520.534
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	SB-209670(CAS:157659-79-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	SB-209670 is a endothelin receptor antagonist. SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog. SB 209670 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B)-receptor activity in the rat. (last updated 6/18/2016).
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Burrell KM, Molenaar P, Dawson PJ, Kaumann AJ. Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: blockade with SB 209670. J Pharmacol Exp Ther. 2000 Jan;292(1):449-59. PubMed PMID: 10604982.

[2]Bunting MW, Widdop RE. Differential haemodynamic effects of endothelin receptor antagonist, SB 209670, in conscious hypertensive and normotensive rats. Eur J Pharmacol. 1999 Sep 17;381(1):13-21. PubMed PMID: 10528129.

[3] Freed MI, Wilson DE, Thompson KA, Harris RZ, Ilson BE, Jorkasky DK. Pharmacokinetics and pharmacodynamics of SB 209670, an endothelin receptor antagonist: effects on the regulation of renal vascular tone. Clin Pharmacol Ther. 1999 May;65(5):473-82. PubMed PMID: 10340912.

[4] Schroeder RL, Keiser JA, Cheng XM, Haleen SJ. PD 142893, SB 209670, and BQ 788 selectively antagonize vascular endothelial versus vascular smooth muscle ET(B)-receptor activity in the rat. J Cardiovasc Pharmacol. 1998 Dec;32(6):935-43. PubMed PMID: 9869499.

[5] Douglas SA, Nichols AJ, Feuerstein GZ, Elliott JD, Ohlstein EH. SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog. J Cardiovasc Pharmacol. 1998;31 Suppl [5]S99-102. PubMed PMID: 9595411.

6: Ishikawa A, Suzuki K, Fujita K. Effect of the endothelin receptor antagonist, SB 209670 on cyclosporine-induced nephrotoxicity. Transplant Proc. 1998 Feb;30(1):40-2. PubMed PMID: 9474951.7: Hay DW, Luttmann MA. Nonpeptide endothelin receptor antagonists. IX. Characterization of endothelin receptors in guinea pig bronchus with SB 209670 and other endothelin receptor antagonists. J Pharmacol Exp Ther. 1997 Feb;280(2):959-65. PubMed PMID: 9023312.8: Gardiner SM, Kemp PA, March JE, Bennett T. Influence of aminoguanidine and the endothelin antagonist, SB 209670, on the regional haemodynamic effects of endotoxaemia in conscious rats. Br J Pharmacol. 1996 Aug;118(7):1822-8. PubMed PMID: 8842449; PubMed Central PMCID: PMC1909836.9: Nambi P, Pullen M, Wu HL, Lee D, Saunders D, Heys R, Aiyar N, Leber J, Elliott J, Brooks D, Ohlstein E, Ruffolo R. Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors. J Pharmacol Exp Ther. 1996 Jun;277(3):1567-71. PubMed PMID: 8667224.10: Ruetten H, Thiemermann C, Vane JR. Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. Br J Pharmacol. 1996 May;118(1):198-204. PubMed PMID: 8733596; PubMed Central PMCID: PMC1909477.1

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