536711-20-3|S39625|(S)-13-cyclobutyl-7-ethyl-7-hydroxy-9,12-dihydro-7H-cyclopenta[6,7]indolizino[1,2-b][1,3]dioxolo[4,5-g]quinoline-8,10-dione|-范德生物科技公司

S39625

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names：
(S)-13-cyclobutyl-7-ethyl-7-hydroxy-9,12-dihydro-7H-cyclopenta[6,7]indolizino[1,2-b][1,3]dioxolo[4,5-g]quinoline-8,10-dione
CAS号：
536711-20-3
MDL Number：
MF(分子式)： C25H22N2O5 MW(分子量)： 430.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-13-cyclobutyl-7-ethyl-7-hydroxy-9,12-dihydro-7H-cyclopenta[6,7]indolizino[1,2-b][1,3]dioxolo[4,5-g]quinoline-8,10-dione
英文别名	S39625; S-39625; S 39625.
CAS号	536711-20-3
Inchi	InChI=1S/C25H22N2O5/c1-2-25(30)16-8-18-23-15(10-27(18)24(29)13(16)7-21(25)28)22(12-4-3-5-12)14-6-19-20(32-11-31-19)9-17(14)26-23/h6,8-9,12,30H,2-5,7,10-11H2,1H3/t25-/m0/s1
InchiKey	BSNSKRNANVCWQN-VWLOTQADSA-N
分子式 Formula	C25H22N2O5
分子量 Molecular Weight	430.46
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	S39625(CAS:536711-20-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	S39625 is an E-ring camptothecin keto analogue. S39625 is stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. Histone gamma-H2AX could be used as a biomarker for the upcoming clinical trials of S39625.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A,Bates SE, Pommier Y. Novel E-ring camptothecin keto analogues (S38809 and S39625)are stable, potent, and selective topoisomerase I inhibitors without beingsubstrates of drug efflux transporters. Mol Cancer Ther. 2007 Dec;6(12 Pt1):3229-38. PubMed PMID: 18089716.