474016-05-2|RWJ 416457|(S)-N-((3-(3-fluoro-4-(2-methyl-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide|-范德生物科技公司

RWJ 416457

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names：
(S)-N-((3-(3-fluoro-4-(2-methyl-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
CAS号：
474016-05-2
MDL Number：
MF(分子式)： C18H20FN5O3 MW(分子量)： 373.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-N-((3-(3-fluoro-4-(2-methyl-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
英文别名	RWJ 416457; RWJ-416457; RWJ416457;
CAS号	474016-05-2
Inchi	InChI=1S/C18H20FN5O3/c1-11(25)20-6-14-9-24(18(26)27-14)13-3-4-17(15(19)5-13)23-8-12-7-22(2)21-16(12)10-23/h3-5,7,14H,6,8-10H2,1-2H3,(H,20,25)/t14-/m0/s1
InchiKey	UCBHICFFJKDMMR-AWEZNQCLSA-N
分子式 Formula	C18H20FN5O3
分子量 Molecular Weight	373.38
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RWJ 416457(CAS:474016-05-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RWJ 416457 is a pyrrolopyrazolyl-substituted oxazolidinone with activity against antibiotic-susceptible and -resistant gram-positive pathogens.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Santoro CM, Bush K, Abbanat D. Characterisation of Staphylococcus aureus and Enterococcus faecalis mutants with reduced susceptibility to the investigational oxazolidinone RWJ-416457. Int J Antimicrob Agents. 2010 Nov;36(5):424-9. doi: 10.1016/j.ijantimicag.2010.07.007. Epub 2010 Sep 17. PubMed PMID: 20846828.

[2]Hilliard JJ, Fernandez J, Melton J, Macielag MJ, Goldschmidt R, Bush K, Abbanat D. In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. Antimicrob Agents Chemother. 2009 May;53(5):2028-33. doi: 10.1128/AAC.00833-08. Epub 2009 Mar 9. PubMed PMID: 19273686; PubMed Central PMCID: PMC2681548.

[3] Cheung EY, Peterson ML, Chiarella R, Foxman BM. A novel oxazolidinone antibiotic: RWJ-416457. Acta Crystallogr C. 2010 May;66(Pt 5):o249-51. doi: 10.1107/S0108270110009339. Epub 2010 Apr 13. PubMed PMID: 20442508.

[4] Tasneen R, Betoudji F, Tyagi S, Li SY, Williams K, Converse PJ, Dartois V, Yang T, Mendel CM, Mdluli KE, Nuermberger EL. Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):270-7. doi: 10.1128/AAC.01691-15. Print 2016 Jan. PubMed PMID: 26503656; PubMed Central PMCID: PMC4704221.

[5] Foleno BD, Abbanat D, Goldschmidt RM, Flamm RK, Paget SD, Webb GC, Wira E, Macielag MJ, Bush K. In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457. Antimicrob Agents Chemother. 2007 Jan;51(1):361-5. Epub 2006 Nov 13. PubMed PMID: 17101672; PubMed Central PMCID: PMC1797661.

6: Livermore DM, Warner M, Mushtaq S, North S, Woodford N. In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci. Antimicrob Agents Chemother. 2007 Mar;51(3):1112-4. Epub 2007 Jan 8. PubMed PMID: 17210773; PubMed Central PMCID: PMC1803128.7: Schmidt S, Sabarinath SN, Barbour A, Abbanat D, Manitpisitkul P, Sha S, Derendorf H. Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2009 Dec;53(12):5039-45. doi: 10.1128/AAC.00633-09. Epub 2009 Sep 28. PubMed PMID: 19786607; PubMed Central PMCID: PMC2786350.8: Dong J, Karki SB, Parikh M, Riggs JC, Huang L. Oxidative degradation studies of an oxazolidinone-derived antibacterial agent, RWJ416457, in aqueous solutions. Drug Dev Ind Pharm. 2012 Nov;38(11):1289-97. Epub 2012 Jan 23. PubMed PMID: 22263626.

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