652978-45-5|RTI-371|3-(4-chlorophenyl)-5-((1S,2S,3S,5R)-8-methyl-3-(p-tolyl)-8-azabicyclo[3.2.1]octan-2-yl)isoxazole|-范德生物科技公司

RTI-371

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names：
3-(4-chlorophenyl)-5-((1S,2S,3S,5R)-8-methyl-3-(p-tolyl)-8-azabicyclo[3.2.1]octan-2-yl)isoxazole
CAS号：
652978-45-5
MDL Number：
MF(分子式)： C24H25ClN2O MW(分子量)： 392.927
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3-(4-chlorophenyl)-5-((1S,2S,3S,5R)-8-methyl-3-(p-tolyl)-8-azabicyclo[3.2.1]octan-2-yl)isoxazole
英文别名	RTI-4229-371; RTI 4229-371; RTI4229-371; RTI-371; RTI371; RTI 371.
CAS号	652978-45-5
Inchi	InChI=1S/C24H25ClN2O/c1-15-3-5-16(6-4-15)20-13-19-11-12-22(27(19)2)24(20)23-14-21(26-28-23)17-7-9-18(25)10-8-17/h3-10,14,19-20,22,24H,11-13H2,1-2H3/t19-,20-,22+,24+/m1/s1
InchiKey	MUVQRHMVRFZUGP-WOOVXOMTSA-N
分子式 Formula	C24H25ClN2O
分子量 Molecular Weight	392.927
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RTI-371(CAS:652978-45-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RTI-371, also known as RTI-4229-371, is a potent and selective dopamine reuptake inhibitor in vitro. RTI-371 and several other DAT-selective inhibitors with atypical actions on locomotor behaviour increased the efficacy of CP55940 in a concentration-dependent manner.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Navarro HA, Howard JL, Pollard GT, Carroll FI. Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. Br J Pharmacol. 2009 Apr;156(7):1178-84. doi: 10.1111/j.1476-5381.2009.00124.x. PubMed PMID: 19226282; PubMed Central PMCID: PMC2697692.

[2]Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL. 2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter. J Pharmacol Exp Ther. 2014 May;349(2):297-309. doi: 10.1124/jpet.113.212738. Erratum in: J Pharmacol Exp Ther. 2014 Jun 1;349(3):534. PubMed PMID: 24518035; PubMed Central PMCID: PMC3989806.

[3] Carroll FI, Pawlush N, Kuhar MJ, Pollard GT, Howard JL. Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. J Med Chem. 2004 Jan 15;47(2):296-302. PubMed PMID: 14711303.

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