104060-12-0|RS-93522|3-(4-(2,3-dihydroxypropoxy)phenethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate|-范德生物科技公司

RS-93522

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names：
3-(4-(2,3-dihydroxypropoxy)phenethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS号：
104060-12-0
MDL Number：
MF(分子式)： C27H30N2O9 MW(分子量)： 526.542
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	3-(4-(2,3-dihydroxypropoxy)phenethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
英文别名	RS-93522; RS 93522; RS93522
CAS号	104060-12-0
Inchi	InChI=1S/C27H30N2O9/c1-16-23(26(32)36-3)25(19-5-4-6-20(13-19)29(34)35)24(17(2)28-16)27(33)37-12-11-18-7-9-22(10-8-18)38-15-21(31)14-30/h4-10,13,21,25,28,30-31H,11-12,14-15H2,1-3H3
InchiKey	QLNAYPDWIWUVHP-UHFFFAOYSA-N
分子式 Formula	C27H30N2O9
分子量 Molecular Weight	526.542
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RS-93522(CAS:104060-12-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RS-93522 is a calcium channel antagonist potentially for the treatment of hypertension. RS-93522 had the additional property of inhibiting phosphodiesterase activity in myocardial homogenates with IC50 = 1.6 x 10(-5)M; the potency and efficacy of phosphodiesterase inhibition was similar to that for milrinone in the same system. As expected of Ca channel antagonists, it has a negative inotropic effect on cultured myocardial cells. RS-93522 also has phosphodiesterase inhibitory activity that possibly may potentiate vasodilatation and ameliorate, in part, negative inotropic effects.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Fu RC, Whatley JL, Fleitman JS. Intranasal delivery of RS-93522, a dihydropyridine-type calcium-channel antagonist. Pharm Res. 1991 Jan;8(1):134-5. PubMed PMID: 2014202.

[2]Kern JR, Lokensgard DM, Yang TY. Chromatographic separation of the diastereomers of a dihydropyridine-type calcium channel antagonist as the bis-3,5-dinitrobenzoates. J Chromatogr. 1988 Dec 21;457:309-16. PubMed PMID: 3243886.

[3] Lidgate DM, Felgner PL, Fleitman JS, Whatley J, Fu RC. In vitro and in vivo studies evaluating a liposome system for drug solubilization. Pharm Res. 1988 Dec;5(12):759-64. PubMed PMID: 3247285.

[4] Marsh JD, Dionne MA, Chiu M, Smith TW. A dihydropyridine calcium channel blocker with phosphodiesterase inhibitory activity: effects on cultured vascular smooth muscle and cultured heart cells. J Mol Cell Cardiol. 1988 Dec;20(12):1141-50. PubMed PMID: 2470909.

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