135729-55-4|RS 42358-197|(S)-2-(quinuclidin-3-yl)-2,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-1-one hydrochloride|-范德生物科技公司

RS 42358-197

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names：
(S)-2-(quinuclidin-3-yl)-2,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-1-one hydrochloride
CAS号：
135729-55-4
MDL Number：
MF(分子式)： C19H23ClN2O MW(分子量)： 330.85
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(S)-2-(quinuclidin-3-yl)-2,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-1-one hydrochloride
英文别名	RS 42358-197; RS42358-197; RS-42358-197;
CAS号	135729-55-4
Inchi	InChI=1S/C19H22N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,11,13,17H,1,3,5,7-10,12H2;1H/t17-;/m1./s1
InchiKey	PEMWWRCTBNOHCX-UNTBIKODSA-N
分子式 Formula	C19H23ClN2O
分子量 Molecular Weight	330.85
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RS 42358-197(CAS:135729-55-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RS 42358-197 is the S-isomer of the novel 5-HT3 receptor antagonist RS-42358.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Costall B, Domeney AM, Kelly ME, Tomkins DM, Naylor RJ, Wong EH, Smith WL, Whiting RL, Eglen RM. The effect of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety. Eur J Pharmacol. 1993 Mar 30;234(1):91-9. PubMed PMID: 8097165.

[2]Eglen RM, Lee CH, Smith WL, Johnson LG, Whiting RL, Hegde SS. RS 42358-197, a novel and potent 5-HT3 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther. 1993 Aug;266(2):535-43. PubMed PMID: 8355189.

[3] Wong EH, Bonhaus DW, Wu I, Stefanich E, Eglen RM. Labelling of 5-hydroxytryptamine3 receptors with a novel 5-HT3 receptor ligand, [3H]RS-42358-197. J Neurochem. 1993 Mar;60(3):921-30. PubMed PMID: 8436978.

[4] Bonhaus DW, Wong EH, Stefanich E, Kunysz EA, Eglen RM. Pharmacological characterization of 5-hydroxytryptamine3 receptors in murine brain and ileum using the novel radioligand [3H]RS-42358-197: evidence for receptor heterogeneity. J Neurochem. 1993 Nov;61(5):1927-32. PubMed PMID: 8229003.

[5] Wong EH, Bonhaus DW, Eglen RM. The identification of heterogeneity of 5-HT3 receptors with [3H]RS-42358-197. Adv Exp Med Biol. 1995;36

3:97-108. PubMed PMID: 7618534.

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