119813-87-5|RS 15385-197|(8aR,12aS,13aS)-3-methoxy-12-(methylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine|-范德生物科技公司

RS 15385-197

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names：
(8aR,12aS,13aS)-3-methoxy-12-(methylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine
CAS号：
119813-87-5
MDL Number：
MF(分子式)： C18H26N2O3S MW(分子量)： 350.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(8aR,12aS,13aS)-3-methoxy-12-(methylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine
英文别名	RS 15385-197; RS-15385-197; RS15385-197;
CAS号	119813-87-5
Inchi	InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m1/s1
InchiKey	JKDBLHWERQWYKF-JLSDUUJJSA-N
分子式 Formula	C18H26N2O3S
分子量 Molecular Weight	350.47
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RS 15385-197(CAS:119813-87-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RS 15385-197 is a potent and selective alpha 2-adrenoceptor antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tallentire D, McRae G, Spedding M, Clark R, Vickery B. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996 May;118(1):63-72. PubMed PMID: 8733577; PubMed Central PMCID: PMC1909492.

[2]Brown CM, MacKinnon AC, Redfern WS, Hicks PE, Kilpatrick AT, Small C, Ramcharan M, Clague RU, Clark RD, MacFarlane CB, et al. The pharmacology of RS-15385-197, a potent and selective alpha 2-adrenoceptor antagonist. Br J Pharmacol. 1993 Feb;108(2):516-25. PubMed PMID: 8095420; PubMed Central PMCID: PMC1908001.

[3] Hume SP, Hirani E, Opacka-Juffry J, Osman S, Myers R, Gunn RN, McCarron JA, Clark RD, Melichar J, Nutt DJ, Pike VW. Evaluation of [O-methyl-11C]RS-15385-197 as a positron emission tomography radioligand for central alpha2-adrenoceptors. Eur J Nucl Med. 2000 May;27(5):475-84. PubMed PMID: 10853800.

[4] MacKinnon AC, Kilpatrick AT, Kenny BA, Spedding M, Brown CM. [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification. Br J Pharmacol. 1992 Aug;106(4):1011-8. PubMed PMID: 1327384; PubMed Central PMCID: PMC1907641.

[5] Redfern WS, MacKinnon AC, Brown CM, Martin AB, Kilpatrick AT, Clague RU, Spedding M. Modulation of central noradrenergic function by RS-15385-197. Br J Pharmacol. 1993 Feb;108(2):526-33. PubMed PMID: 8095421; PubMed Central PMCID: PMC1907981.

6: Spedding M, Newman-Tancredi A, Millan MJ, Dacquet C, Michel AN, Jacoby E, Vickery B, Tallentire D. Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Neuropharmacology. 1998 Jun;37(6):769-80. PubMed PMID: 9707291.7: MacKinnon AC, Spedding M, Brown CM. Sodium modulation of 3H-agonist and 3H-antagonist binding to alpha 2-adrenoceptor subtypes. Br J Pharmacol. 1993 Jun;109(2):371-8. PubMed PMID: 8102928; PubMed Central PMCID: PMC2175701.8: Redfern WS, Williams A. A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat. Br J Pharmacol. 1995 Oct;116(3):2081-9. PubMed PMID: 8640349; PubMed Central PMCID: PMC1908953.9: MacKinnon AC, Stewart M, Olverman HJ, Spedding M, Brown CM. [3H]p-aminoclonidine and [3H]idazoxan label different populations of imidazoline sites on rat kidney. Eur J Pharmacol. 1993 Feb 23;232(1):79-87. PubMed PMID: 8096190.10: Bancroft J, Munoz M, Beard M, Shapiro C. The effects of a new alpha-2 adrenoceptor antagonist on sleep and nocturnal penile tumescence in normal male volunteers and men with erectile dysfunction. Psychosom Med. 1995 Jul-Aug;57(4):345-56. PubMed PMID: 7480564.1

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