144284-57-1|Ro 31-8472|6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-carboxy-3-(4-hydroxyphenyl)propyl)amino)octahydro-10-oxo-, (1S-(1alpha,9alpha(R*)))-|-范德生物科技公司

Ro 31-8472

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names：
6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-carboxy-3-(4-hydroxyphenyl)propyl)amino)octahydro-10-oxo-, (1S-(1alpha,9alpha(R*)))-
CAS号：
144284-57-1
MDL Number：
MF(分子式)： C20H27N3O6 MW(分子量)： 405.45
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	6H-Pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid, 9-((1-carboxy-3-(4-hydroxyphenyl)propyl)amino)octahydro-10-oxo-, (1S-(1alpha,9alpha(R*)))-
英文别名	Ro 31-8472; Ro 318472; Ro-31-8472.
CAS号	144284-57-1
Inchi	InChI=1S/C20H27N3O6/c24-14-8-5-13(6-9-14)7-10-16(19(26)27)21-15-3-1-11-22-12-2-4-17(20(28)29)23(22)18(15)25/h5-6,8-9,15-17,21,24H,1-4,7,10-12H2,(H,26,27)(H,28,29)/t15-,16-,17-/m0/s1
InchiKey	DJJGMVZKUBHPAB-ULQDDVLXSA-N
分子式 Formula	C20H27N3O6
分子量 Molecular Weight	405.45
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ro 31-8472(CAS:144284-57-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ro 31-8472 is an angiotensin-converting enzyme (ACE) inhibitor and an analog of cilazaprilat.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bevilacqua M, Vago T, Rogolino A, Conci F, Santoli E, Norbiato G. Affinity of angiotensin I-converting enzyme (ACE) inhibitors for N- and C-binding sites of human ACE is different in heart, lung, arteries, and veins. J Cardiovasc Pharmacol. 1996 Oct;28(4):494-9. PubMed PMID: 8891872.

[2]Vago T, Bevilacqua M, Conci F, Rogolino A, Norbiato G. Pharmacologic data reveal the heterogeneity of angiotensin-converting enzyme according to its source (lung versus heart). Am J Cardiol. 1995 Jun 16;75(18):13F-17F. PubMed PMID: 7778528.

[3] Perich RB, Jackson B, Johnston CI. Structural constraints of inhibitors for binding at two active sites on somatic angiotensin converting enzyme. Eur J Pharmacol. 1994 Feb 15;266(3):201-11. PubMed PMID: 8174603.

[4] Perich RB, Jackson B, Rogerson F, Mendelsohn FA, Paxton D, Johnston CI. Two binding sites on angiotensin-converting enzyme: evidence from radioligand binding studies. Mol Pharmacol. 1992 Aug;42(2):286-93. PubMed PMID: 1325031.

[5] Perich RB, Jackson B, Johnston CI. Variation in angiotensin-converting enzyme (ACE) inhibitor affinity at two binding sites on rat pulmonary ACE: influence on bradykinin hydrolysis. Clin Exp Pharmacol Physiol. 1992 May;19(5):353-7. PubMed PMID: 1325885.

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