99832-61-8|RH 3421|methyl 3-(4-chlorophenyl)-4-methyl-1-((4-(trifluoromethyl)phenyl)carbamoyl)-4,5-dihydro-1H-pyrazole-4-carboxylate|-范德生物科技公司

RH 3421

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names：
methyl 3-(4-chlorophenyl)-4-methyl-1-((4-(trifluoromethyl)phenyl)carbamoyl)-4,5-dihydro-1H-pyrazole-4-carboxylate
CAS号：
99832-61-8
MDL Number：
MF(分子式)： C20H17ClF3N3O3 MW(分子量)： 439.81
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	methyl 3-(4-chlorophenyl)-4-methyl-1-((4-(trifluoromethyl)phenyl)carbamoyl)-4,5-dihydro-1H-pyrazole-4-carboxylate
英文别名	RH 3421; RH-3421; RH3421;
CAS号	99832-61-8
Inchi	InChI=1S/C20H17ClF3N3O3/c1-19(17(28)30-2)11-27(26-16(19)12-3-7-14(21)8-4-12)18(29)25-15-9-5-13(6-10-15)20(22,23)24/h3-10H,11H2,1-2H3,(H,25,29)
InchiKey	NWYXCHPAIGQKNN-UHFFFAOYSA-N
分子式 Formula	C20H17ClF3N3O3
分子量 Molecular Weight	439.81
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	RH 3421(CAS:99832-61-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	RH 3421 is a neuroactive dihydropyrazole insecticide.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Nicholson RA, Williams MF. Sub-chronic administration of ethanol to mice does not modify the inhibitory effects of dieldrin, abamectin and the dihydropyrazole RH-3421 at their respective sites of action in the nervous system. Comp Biochem Physiol C. 1993 May;105(1):69-72. PubMed PMID: 7687943.

[2]Tsurubuchi Y, Zhao X, Nagata K, Kono Y, Nishimura K, Yeh JZ, Narahashi T. Modulation of tetrodotoxin-resistant sodium channels by dihydropyrazole insecticide RH-3421 in rat dorsal root ganglion neurons. Neurotoxicology. 2001 Dec;22(6):743-53. PubMed PMID: 11829408.

[3] Zhang A, Nicholson RA. RH-3421, a potent dihydropyrazole insecticide, inhibits depolarization-stimulated rises in free [Ca2+] and 45Ca2+ uptake in mammalian synaptosomes. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1994 Jul;108(3):307-10. PubMed PMID: 7881802.

[4] Silver K, Soderlund DM. State-dependent block of rat Nav1.4 sodium channels expressed in xenopus oocytes by pyrazoline-type insecticides. Neurotoxicology. 2005 Jun;26(3):397-406. PubMed PMID: 15935211.

[5] Silver KS, Soderlund DM. Differential sensitivity of rat voltage-sensitive sodium channel isoforms to pyrazoline-type insecticides. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):209-17. Epub 2006 Feb 17. PubMed PMID: 16487558.

6: von Stein RT, Soderlund DM. Compound-specific effects of mutations at Val787 in DII-S6 of Nav 1.4 sodium channels on the action of sodium channel inhibitor insecticides. Neurotoxicology. 2012 Oct;33(5):1381-9. doi: 10.1016/j.neuro.2012.09.003. Epub 2012 Sep 14. PubMed PMID: 22983119; PubMed Central PMCID: PMC3484372.7: Waliwitiya R, Belton P, Nicholson RA, Lowenberger CA. Plant terpenoids: acute toxicities and effects on flight motor activity and wing beat frequency in the blow fly Phaenicia sericata. J Econ Entomol. 2012 Feb;105(1):72-84. PubMed PMID: 22420258.8: Salgado VL. Slow voltage-dependent block of sodium channels in crayfish nerve by dihydropyrazole insecticides. Mol Pharmacol. 1992 Jan;41(1):120-6. PubMed PMID: 1310138.9: Silver KS, Soderlund DM. Point mutations at the local anesthetic receptor site modulate the state-dependent block of rat Na v1.4 sodium channels by pyrazoline-type insecticides. Neurotoxicology. 2007 May;28(3):655-63. Epub 2007 Feb 11. PubMed PMID: 17367864.

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