426253-04-5|Razupenem|(4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-3-((4-((S)-5-methyl-2,5-dihydro-1H-pyrrol-3-yl)thiazol-2-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid|-范德生物科技公司

Razupenem

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names：
(4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-3-((4-((S)-5-methyl-2,5-dihydro-1H-pyrrol-3-yl)thiazol-2-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CAS号：
426253-04-5
MDL Number：
MF(分子式)： C18H21N3O4S2 MW(分子量)： 407.503
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	(4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-3-((4-((S)-5-methyl-2,5-dihydro-1H-pyrrol-3-yl)thiazol-2-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
英文别名	SMP-601; SMP601; SMP 601; PTZ601; PTZ-601; PTZ 601; PZ-601; SM-216601; SM 216601; SM216601; Razupenem.
CAS号	426253-04-5
SMILES	O=C(C(N12)=C(SC3=NC(C4=C[C@H](C)NC4)=CS3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
Inchi	InChI=1S/C18H21N3O4S2/c1-7-4-10(5-19-7)11-6-26-18(20-11)27-15-8(2)13-12(9(3)22)16(23)21(13)14(15)17(24)25/h4,6-9,12-13,19,22H,5H2,1-3H3,(H,24,25)/t7-,8+,9+,12+,13+/m0/s1
InchiKey	XFGOMLIRJYURLQ-GOKYHWASSA-N
分子式 Formula	C18H21N3O4S2
分子量 Molecular Weight	407.503
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Razupenem(CAS:426253-04-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Razupenem, also known as SMP-601 and PTZ601, is a broad spectrum injectable antibiotic, from the carbapenem subgroup of beta-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. Razupenem performed well against a variety of bacterial strains.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ansari MA, Shaikh S, Shakil S, Rizvi SM. An enzoinformatics study for prediction of efficacies of three novel penem antibiotics against New Delhi metallo-β-lactamase-1 bacterial enzyme. Interdiscip Sci. 2014 Sep;6(3):208-15. doi: 10.1007/s12539-013-0202-9. Epub 2014 Sep 1[1]PubMed PMID: 25205498.

[2]Ansari MA, Shaikh S, Shakil S, Rizvi SM. An enzoinformatics study for prediction of efficacies of three novel penem antibiotics against New Delhi metallo-β-lactamase-1 bacterial enzyme. Interdiscip Sci. 2014 Aug 9. [Epub ahead of print] PubMed PMID: 25118651.

[3] Tran QT, Pearlstein RA, Williams S, Reilly J, Krucker T, Erdemli G. Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin. Proteins. 2014 Nov;82(11):2998-3012. doi: 10.1002/prot.24659. Epub 2014 Aug 21. PubMed PMID: 25082756.

[4] Karpiuk I, Tyski S. Looking for the new preparations for antibacterial therapy. II. Clinical trials; new beta-lactam antibiotics and beta-lactamase inhibitors. Przegl Epidemiol. 2013;67(1):51-6, 135-40. English, Polish. PubMed PMID: 23745376.

[5] Tran CM, Tanaka K, Yamagishi Y, Goto T, Mikamo H, Watanabe K. In vitro antimicrobial activity of razupenem (SMP-601, PTZ601) against anaerobic bacteria. Antimicrob Agents Chemother. 2011 May;55(5):2398-402. doi: 10.1128/AAC.01038-10. Epub 2011 Feb 22. PubMed PMID: 21343447; PubMed Central PMCID: PMC3088197.

6: MacGowan AP, Noel A, Tomaselli S, Elliott H, Bowker K. Pharmacodynamics of razupenem (PZ601) studied in an in vitro pharmacokinetic model of infection. Antimicrob Agents Chemother. 2011 Apr;55(4):1436-42. doi: 10.1128/AAC.00936-10. Epub 2011 Jan 24. PubMed PMID: 21263054; PubMed Central PMCID: PMC3067199.7: Page MG, Heim J. New molecules from old classes: revisiting the development of beta-lactams. IDrugs. 2009 Sep;12(9):561-5. PubMed PMID: 19697275.8: Livermore DM. Has the era of untreatable infections arrived? J Antimicrob Chemother. 2009 Sep;64 Suppl 1:i29-36. doi: 10.1093/jac/dkp255. Review. PubMed PMID: 19675016.9: Livermore DM, Mushtaq S, Warner M. Activity of the anti-MRSA carbapenem razupenem (PTZ601) against Enterobacteriaceae with defined resistance mechanisms. J Antimicrob Chemother. 2009 Aug;64(2):330-5. doi: 10.1093/jac/dkp187. Epub 2009 Jun 4. PubMed PMID: 19497942.10: Clark C, Kosowska-Shick K, McGhee P, Dewasse B, Beachel L, Appelbaum PC. Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains. Antimicrob Agents Chemother. 2009 Jul;53(7):3118-21. doi: 10.1128/AAC.00183-09. Epub 2009 May 11. PubMed PMID: 19433566; PubMed Central PMCID: PMC2704702.

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