78668-34-5|Pyclen|3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene|-范德生物科技公司

Pyclen

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names：
3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene
CAS号：
78668-34-5
MDL Number：
MF(分子式)： C11H18N4 MW(分子量)： 206.29
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene
英文别名	Pyclen;
CAS号	78668-34-5
Inchi	InChI=1S/C11H18N4/c1-2-10-8-13-6-4-12-5-7-14-9-11(3-1)15-10/h1-3,12-14H,4-9H2
InchiKey	LNMUPMQUMCDOKO-UHFFFAOYSA-N
分子式 Formula	C11H18N4
分子量 Molecular Weight	206.29
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Pyclen(CAS:78668-34-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Pyclen is an inhibitor of cell death induced by oxidative stress and inhibitor of AB1-40 aggregation induced by Cu2+ ion. It is capable of both preventing and disrupting Cu(2+) induced AB(1-40) aggregation.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
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备注

[1]Le Fur M, Beyler M, Lepareur N, Fougère O, Platas-Iglesias C, Rousseaux O, Tripier R. Pyclen Tri-n-butylphosphonate Ester as Potential Chelator for Targeted Radiotherapy: From Yttrium(III) Complexation to (90)Y Radiolabeling. Inorg Chem. 2016 Aug 15;55(16):8003-12. doi: 10.1021/acs.inorgchem.6b01135. Epub 2016 Aug 3. PubMed PMID: 27486673.

[2]Lincoln KM, Gonzalez P, Richardson TE, Julovich DA, Saunders R, Simpkins JW, Green KN. A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders. Chem Commun (Camb). 2013 Apr 4;49(26):2712-4. doi: 10.1039/c2cc36808k. PubMed PMID: 23437435; PubMed Central PMCID: PMC4446701.

[3] Lincoln KM, Richardson TE, Rutter L, Gonzalez P, Simpkins JW, Green KN. An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation. ACS Chem Neurosci. 2012 Nov 21;3(11):919-27. doi: 10.1021/cn300060v. Epub 2012 Aug 31. PubMed PMID: 23173072; PubMed Central PMCID: PMC3503443.

[4] Lincoln KM, Offutt ME, Hayden TD, Saunders RE, Green KN. Structural, spectral, and electrochemical properties of nickel(II), copper(II), and zinc(II) complexes containing 12-membered pyridine- and pyridol-based tetra-aza macrocycles. Inorg Chem. 2014 Feb 3;53(3):1406-16. doi: 10.1021/ic402119s. Epub 2014 Jan 17. PubMed PMID: 24437677.

[5] Le Fur M, Beyler M, Molnár E, Fougère O, Esteban-Gómez D, Tircsó G, Platas-Iglesias C, Lepareur N, Rousseaux O, Tripier R. The role of the capping bond effect on pyclen (nat)Y(3+)/(90)Y(3+) chelates: full control of the regiospecific N-functionalization makes the difference. Chem Commun (Camb). 2017 Aug 24;53(69):9534-9537. doi: 10.1039/c7cc05088g. PubMed PMID: 28808725.

6: Le Fur M, Beyler M, Molnár E, Fougère O, Esteban-Gómez D, Tircsó G, Platas-Iglesias C, Lepareur N, Rousseaux O, Tripier R. Stable and Inert Yttrium(III) Complexes with Pyclen-Based Ligands Bearing Pendant Picolinate Arms: Toward New Pharmaceuticals for β-Radiotherapy. Inorg Chem. 2018 Feb 19;57(4):2051-2063. doi: 10.1021/acs.inorgchem.7b02953. Epub 2018 Feb 5. PubMed PMID: 29400452.7: Le Fur M, Molnár E, Beyler M, Fougère O, Esteban-Gómez D, Rousseaux O, Tripier R, Tircsó G, Platas-Iglesias C. Expanding the Family of Pyclen-Based Ligands Bearing Pendant Picolinate Arms for Lanthanide Complexation. Inorg Chem. 2018 Jun 18;57(12):6932-6945. doi: 10.1021/acs.inorgchem.8b00598. Epub 2018 May 30. PubMed PMID: 29846067.8: Hamon N, Galland M, Le Fur M, Roux A, Duperray A, Grichine A, Andraud C, Le Guennic B, Beyler M, Maury O, Tripier R. Combining a pyclen framework with conjugated antenna for the design of europium and samarium luminescent bioprobes. Chem Commun (Camb). 2018 Jun 12;54(48):6173-6176. doi: 10.1039/c8cc02035c. PubMed PMID: 29845153.9: Le Fur M, Molnár E, Beyler M, Kálmán FK, Fougère O, Esteban-Gómez D, Rousseaux O, Tripier R, Tircsó G, Platas-Iglesias C. A Coordination Chemistry Approach to Fine-Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications. Chemistry. 2018 Mar 2;24(13):3127-3131. doi: 10.1002/chem.201705528. Epub 2018 Feb 6. PubMed PMID: 29243854.

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