2324-94-9|Profadol hydrochloride|m-(1-Methyl-3-propyl-3-pyrrolidinyl)phenol hydrochloride|-范德生物科技公司

Profadol hydrochloride

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names：
m-(1-Methyl-3-propyl-3-pyrrolidinyl)phenol hydrochloride
CAS号：
2324-94-9
MDL Number：
MF(分子式)： C14H22ClNO MW(分子量)： 255.79
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	m-(1-Methyl-3-propyl-3-pyrrolidinyl)phenol hydrochloride
英文别名	Profadol hydrochloride; Profadol HCl; A-2205; Centrac; CI 572; CI-572.
CAS号	2324-94-9
Inchi	InChI=1S/C14H21NO.ClH/c1-3-7-14(8-9-15(2)11-14)12-5-4-6-13(16)10-12;/h4-6,10,16H,3,7-9,11H2,1-2H3;1H
InchiKey	HRCGIZACAMIMII-UHFFFAOYSA-N
分子式 Formula	C14H22ClNO
分子量 Molecular Weight	255.79
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Profadol hydrochloride(CAS:2324-94-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Profadol hydrochloride is discontinued (DEA controlled substance). Profadol hydrochloride is an opioid analgesic. It acts as a mixed agonist-antagonist of the μ-opioid receptor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Picker MJ, Smith MA, Morgan D. Assessment of the relative intrinsic efficacy of profadol and meperidine in a pigeon drug discrimination procedure: relevance to partial substitution patterns. Behav Pharmacol. 1994 Feb;5(1):61-70. PubMed PMID: 11224252.

[2]Rhodes KF. Yohimbine antagonism of the inhibitory effects of pethidine and profadol in the mouse isolated vas deferens. J Pharm Pharmacol. 1983 Mar;35(3):182-3. PubMed PMID: 6132980.

[3] Crooks PA, Sommerville R. The synthesis and analgesic activities of some spiro[indan-1,3'-pyrrolidine] derivatives designed as rigid analogs of profadol. J Pharm Sci. 1982 Mar;71(3):291-4. PubMed PMID: 6461753.

[4] Leander JD. Effects of profadol on operant behavior in the pigeon. Pharmacol Biochem Behav. 1982 Mar;16(3):487-90. PubMed PMID: 6210915.

[5] Crooks PA, Szyndler R. Synthesis and analgesic properties of some conformationally restricted analogues of profadol. J Med Chem. 1980 Jun;23(6):679-82. PubMed PMID: 6446605.

6: Holtzman SG. Behavioral effects of profadol in the rat. Psychopharmacologia. 1974 Jan 11;34(2):135-42. PubMed PMID: 4818022.7: Jasinski DR, Martin WR, Hoeldtke R. Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man. Clin Pharmacol Ther. 1971 Jul-Aug;12(4):613-49. PubMed PMID: 5567808.8: Pearson JW, Lasagna L, Laird RD. Analgesic activity of oral and intramuscular profadol. Clin Pharmacol Ther. 1971 Jul-Aug;12(4):683-90. PubMed PMID: 4936041.9: Pearson JW, Landesman RK, Laird RD. Cardiovascular and respiratory effects of profadol in normal individuals. J Clin Pharmacol New Drugs. 1971 Jul-Aug;11(4):261-7. PubMed PMID: 4932742.10: Bowman RE. Profadol--a new potent analgesic. Chem Ind. 1969 Aug 9;3

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