143383-65-7|Premafloxacin|1-cyclopropyl-6-fluoro-8-methoxy-7-[(3R)-3-[(1S)-1-(methylamino)ethyl]pyrrolidin-1-yl]-4-oxoquinoline-3-carboxylic acid|-范德生物科技公司

Premafloxacin

NMR下载 COA and HPLC MSDS下载
names：
1-cyclopropyl-6-fluoro-8-methoxy-7-[(3R)-3-[(1S)-1-(methylamino)ethyl]pyrrolidin-1-yl]-4-oxoquinoline-3-carboxylic acid
CAS号：
143383-65-7
MDL Number：
MF(分子式)： C21H26FN3O4 MW(分子量)： 403.4544
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	1-cyclopropyl-6-fluoro-8-methoxy-7-[(3R)-3-[(1S)-1-(methylamino)ethyl]pyrrolidin-1-yl]-4-oxoquinoline-3-carboxylic acid
英文别名	Premafloxacin; U-95376; U95376; U 95376
CAS号	143383-65-7
Inchi	InChI=1S/C21H26FN3O4/c1-11(23-2)12-6-7-24(9-12)18-16(22)8-14-17(20(18)29-3)25(13-4-5-13)10-15(19(14)26)21(27)28/h8,10-13,23H,4-7,9H2,1-3H3,(H,27,28)/t11-,12+/m0/s1
InchiKey	SUQUWONDIBHQOZ-NWDGAFQWSA-N
分子式 Formula	C21H26FN3O4
分子量 Molecular Weight	403.4544
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Premafloxacin(CAS:143383-65-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Premafloxacin is an 8-methoxy fluoroquinolone with enhanced activity against Staphylococcus aureus.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bao DH, Gu XS, Xie JH, Zhou QL. Iridium-Catalyzed Asymmetric Hydrogenation of Racemic β-Keto Lactams via Dynamic Kinetic Resolution. Org Lett. 2017 Jan 6;19(1):118-12[1]doi: 10.1021/acs.orglett.6b03397. Epub 2016 Dec 12. PubMed PMID: 27936808.

[2]Fioritto AF, Bhattachar SN, Wesley JA. Solubility measurement of polymorphic compounds via the pH-metric titration technique. Int J Pharm. 2007 Feb 7;330(1-2):105-13. Epub 2006 Sep 10. PubMed PMID: 17049191.

[3] Sakai T, Kawamoto Y, Tomioka K. Asymmetric synthesis of intermediates for otamixaban and premafloxacin by the chiral ligand-controlled asymmetric conjugate addition of a lithium amide. J Org Chem. 2006 Jun 9;71(12):4706-9. PubMed PMID: 16749814.

[4] Wang M, Sahm DF, Jacoby GA, Zhang Y, Hooper DC. Activities of newer quinolones against Escherichia coli and Klebsiella pneumoniae containing the plasmid-mediated quinolone resistance determinant qnr. Antimicrob Agents Chemother. 2004 Apr;48(4):1400-1. PubMed PMID: 15047552; PubMed Central PMCID: PMC375334.

[5] Fleck TJ, McWhorter WW Jr, DeKam RN, Pearlman BA. Synthesis of N-methyl-N-[(1S)-1-[(3R)-pyrrolidin-3-yl]ethyl]amine. J Org Chem. 2003 Dec 12;68(25):9612-7. PubMed PMID: 14656085.

6: Ince D, Hooper DC. Quinolone resistance due to reduced target enzyme expression. J Bacteriol. 2003 Dec;185(23):6883-92. PubMed PMID: 14617652; PubMed Central PMCID: PMC262703.7: Chang CF, Chang LC, Chang YF, Chen M, Chiang TS. Antimicrobial susceptibility of Actinobacillus pleuropneumoniae, Escherichia coli, and Salmonella choleraesuis recovered from Taiwanese swine. J Vet Diagn Invest. 2002 Mar;14(2):153-7. PubMed PMID: 11939337.8: Gu CH, Grant DJ. Estimating the relative stability of polymorphs and hydrates from heats of solution and solubility data. J Pharm Sci. 2001 Sep;90(9):1277-87. PubMed PMID: 11745780.9: Ince D, Hooper DC. Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions. Antimicrob Agents Chemother. 2000 Dec;44(12):3344-50. PubMed PMID: 11083638; PubMed Central PMCID: PMC90203.10: De Oliveira AP, Watts JL, Salmon SA, Aarestrup FM. Antimicrobial susceptibility of Staphylococcus aureus isolated from bovine mastitis in Europe and the United States. J Dairy Sci. 2000 Apr;83(4):855-62. PubMed PMID: 10791803.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开