70111-54-5|Loprazolam mesylate|(Z)-6-(2-chlorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-2,4-dihydro-1H-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one methanesulfonate|-范德生物科技公司

Loprazolam mesylate

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names：
(Z)-6-(2-chlorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-2,4-dihydro-1H-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one methanesulfonate
CAS号：
70111-54-5
MDL Number：
MF(分子式)： C24H25ClN6O6S MW(分子量)： 561.01
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Loprazolam mesylate
英文别名	Loprazolam mesylate; Sonin; RU-31158; RU 31158; RU31158; HR 158; Dormonoct; Somnovit;
CAS号	70111-54-5
Inchi	InChI=1S/C23H21ClN6O3.CH4O3S/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24;1-5(2,3)4/h2-7,12,14H,8-11,13H2,1H3;1H3,(H,2,3,4)/b19-14-;
InchiKey	DDSDPQHQLNAGLJ-YEBWQKSTSA-N
分子式 Formula	C24H25ClN6O6S
分子量 Molecular Weight	561.01
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Loprazolam mesylate(CAS:70111-54-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Loprazolam mesylate is discontinued (DEA controlled substance). Loprazolam mesylate an imidazolobenzodiazepine derivative with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]McManus IC, Ankier SI, Norfolk J, Phillips M, Priest RG. Effects on psychological performance of the benzodiazepine, loprazolam, alone and with alcohol. Br J Clin Pharmacol. 1983 Sep;16(3):291-300. PubMed PMID: 6138055; PubMed Central PMCID: PMC1428001.

[2]Jochemsen R, van Rijn PA, Hazelzet TG, van Boxtel CJ, Breimer DD. Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration. Biopharm Drug Dispos. 1986 Jan-Feb;7(1):53-61. PubMed PMID: 2869795.

[3] Stevens LA, Pidgen AW, Bevan CD, Ings RM, Lawrence JR, McEwen J. Correlation of the clinical pharmacodynamics of loprazolam with serum concentration. Xenobiotica. 1985 Jul;15(7):623-31. PubMed PMID: 4049902.

[4] Illing HP, Bevan CD, Robinson JD, Chamberlain J, Fromson JM. Metabolism of loprazolam in rat, dog and man in vivo. Xenobiotica. 1983 Sep;13(9):539-53. PubMed PMID: 6659550.

[5] Mamelak M, Bunting P, Galin H, Price V, Csima A, Young T, Klein D, Pelchat JR. Serum and quantitative electroencephalographic pharmacokinetics of loprazolam in the elderly. J Clin Pharmacol. 1988 Apr;28(4):376-83. PubMed PMID: 3392236.

6: Bayer AJ, Pathy MS. Clinical and psychometric evaluation of two doses of loprazolam and placebo in geriatric patients. Curr Med Res Opin. 1986;10(1):17-24. PubMed PMID: 2870876.7: Clark BG, Jue SG, Dawson GW, Ward A. Loprazolam. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in insomnia. Drugs. 1986 Jun;31(6):500-16. Review. PubMed PMID: 2874007.8: Salkind MR, Silverstone T. The clinical and psychometric evaluation of a new hypnotic drug, loprazolam, in general practice. Curr Med Res Opin. 1983;8(5):368-74. PubMed PMID: 6340977.9: Dorling MC, Hindmarch I. Pharmacokinetic profile of loprazolam in 12 young and 12 elderly healthy volunteers. Drugs Exp Clin Res. 2001;27(4):151-9. PubMed PMID: 11822225.10: Swift CG, Swift MR, Ankier SI, Pidgen A, Robinson J. Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly. Br J Clin Pharmacol. 1985 Aug;20(2):119-28. PubMed PMID: 2864049; PubMed Central PMCID: PMC1400680.1

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