26786-84-5|Lomofungin|methyl 6-formyl-4,7,9-trihydroxyphenazine-1-carboxylate|-范德生物科技公司

Lomofungin

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names：
methyl 6-formyl-4,7,9-trihydroxyphenazine-1-carboxylate
CAS号：
26786-84-5
MDL Number：
MF(分子式)： C15H10N2O6 MW(分子量)： 314.25
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lomofungin
英文别名	Lomofungin; NSC 106995; NSC-106995; NSC106995; U-24,792; U 24,792; U24,792; U 24792; U-24792; U24792;
CAS号	26786-84-5
SMILES	O=C(C1=CC=C(O)C2=NC3=C(C=O)C(O)=CC(O)=C3N=C21)OC
Inchi	InChI=1S/C15H10N2O6/c1-23-15(22)6-2-3-8(19)13-11(6)16-14-10(21)4-9(20)7(5-18)12(14)17-13/h2-5,19-21H,1H3
InchiKey	CRANETCJDDEINO-UHFFFAOYSA-N
分子式 Formula	C15H10N2O6
分子量 Molecular Weight	314.25
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lomofungin(CAS:26786-84-5):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lomofungin is an antibiotic obtained from Streptomyces species; reported effective against bacteria as well as fungi & yeasts; probably inhibits nucleic acid & protein synthesis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wang W, Wang H, Hu H, Peng H, Zhang X. Overexpression of afsR and Optimization of Metal Chloride to Improve Lomofungin Production in Streptomyces lomondensis S015. J Microbiol Biotechnol. 2015 May;25(5):672-80. PubMed PMID: 25502821.

[2]Zhang C, Sheng C, Wang W, Hu H, Peng H, Zhang X. Identification of the Lomofungin Biosynthesis Gene Cluster and Associated Flavin-Dependent Monooxygenase Gene in Streptomyces lomondensis S015. PLoS One. 2015 Aug 25;10(8):e0136228. doi: 10.1371/journal.pone.0136228. eCollection 2015. PubMed PMID: 26305803; PubMed Central PMCID: PMC4549113.

[3] Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA. Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic Acids Res. 2014 Jun;42(10):6591-602. doi: 10.1093/nar/gku275. Epub 2014 May 5. PubMed PMID: 24799433; PubMed Central PMCID: PMC4041448.

[4] Ruet A, Bouhet JC, Buhler JM, Sentenac A. On the mode of action of lomofungin, an inhibitor of RNA synthesis in yeast. Biochemistry. 1975 Oct 21;14(21):4651-8. PubMed PMID: 1101954.

[5] Pery E, Sheehy A, Miranda Nebane N, Misra V, Mankowski MK, Rasmussen L, Lucile White E, Ptak RG, Gabuzda D. Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1. Virology. 2015 Oct;48

4:276-87. doi: 10.1016/j.virol.2015.06.014. Epub 2015 Jul 1. PubMed PMID: 26141568; PubMed Central PMCID: PMC4567410.

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