18416-85-8|Lombricine|O-((2-guanidinoethoxy)(hydroxy)phosphoryl)-L-serine|-范德生物科技公司

Lombricine

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names：
O-((2-guanidinoethoxy)(hydroxy)phosphoryl)-L-serine
CAS号：
18416-85-8
MDL Number：
MF(分子式)： C6H15N4O6P MW(分子量)： 270.18
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lombricine
英文别名	Lombricine; L-Lombricine;
CAS号	18416-85-8
SMILES	N[C@@H](COP(O)(OCCNC(N)=N)=O)C(O)=O
Inchi	InChI=1S/C6H15N4O6P/c7-4(5(11)12)3-16-17(13,14)15-2-1-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H,13,14)(H4,8,9,10)/t4-/m0/s1
InchiKey	GSDBGCKBBJVPNC-BYPYZUCNSA-N
分子式 Formula	C6H15N4O6P
分子量 Molecular Weight	270.18
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lombricine(CAS:18416-85-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lombricine is a phosphagen that is unique to earthworms. Structurally, it is a phosphodiester of 2-guanidinoethanol and D-serine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Doumen C. Variable intron/exon structure in the oligochaete lombricine kinase gene. Gene. 2012 Sep 1;505(2):276-82. doi: 10.1016/j.gene.2012.06.007. Epub 2012 Jun 12. PubMed PMID: 22705027.

[2]Bush DJ, Kirillova O, Clark SA, Davulcu O, Fabiola F, Xie Q, Somasundaram T, Ellington WR, Chapman MS. The structure of lombricine kinase: implications for phosphagen kinase conformational changes. J Biol Chem. 2011 Mar 18;286(11):9338-50. doi: 10.1074/jbc.M110.202796. Epub 2011 Jan 6. PubMed PMID: 21212263; PubMed Central PMCID: PMC3058953.

[3] Nagasawa H, Sawaki K, Fujii Y, Kobayashi M, Segawa T, Suzuki R, Inatomi H. Inhibition by lombricine from earthworm (Lumbricus terrestris) of the growth of spontaneous mammary tumours in SHN mice. Anticancer Res. 1991 May-Jun;11(3):1061-4. PubMed PMID: 1909513.

[4] Ellington WR, Bush J. Cloning and expression of a lombricine kinase from an echiuroid worm: insights into structural correlates of substrate specificity. Biochem Biophys Res Commun. 2002 Mar 8;291(4):939-44. PubMed PMID: 11866456.

[5] Doumen C. cDNA identification, comparison and phylogenetic aspects of lombricine kinase from two oligochaete species. Comp Biochem Physiol B Biochem Mol Biol. 2010 Jun;156(2):137-43. doi: 10.1016/j.cbpb.2010.03.002. Epub 2010 Mar 15. PubMed PMID: 20230902.

6: BEATTY IM, MAGRATH DI, ENNOR AH. Occurrence of D-serine in lombricine. Nature. 1959 Feb 28;183(4661):591. PubMed PMID: 13632801.7: ROSENBERG H, ROSSITER RJ, GAFFNEY T, ENNOR AH. Lombricine phosphoryltransferase in earthworms. Biochim Biophys Acta. 1960 Jan 15;37:385-6. PubMed PMID: 14438944.8: BEATTY IM, ENNOR AH, ROSENBERG H, MAGRATH DI. The configuration of the serine moiety of lombricine and reptilian serine ethanolamine phosphodiester. J Biol Chem. 1961 Apr;23

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