246018-80-4|Lobeline, (+)-|2-((2S,6R)-6-((R)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one|-范德生物科技公司

Lobeline, (+)-

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names：
2-((2S,6R)-6-((R)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one
CAS号：
246018-80-4
MDL Number：
MF(分子式)： C22H27NO2 MW(分子量)： 337.46
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lobeline, (+)-
英文别名	Lobeline, (+)-; (+)-Lobeline;
CAS号	246018-80-4
Inchi	InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m1/s1
InchiKey	MXYUKLILVYORSK-QHAWAJNXSA-N
分子式 Formula	C22H27NO2
分子量 Molecular Weight	337.46
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lobeline, (+)-(CAS:246018-80-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lobeline, (+)- is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Dwoskin LP, Crooks PA. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochem Pharmacol. 2002 Jan 15;63(2):89-98. Review. PubMed PMID: 11841781.

[2]Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters. J Pharmacol Exp Ther. 2004 Sep;310(3):1035-45. Epub 2004 Apr 30. PubMed PMID: 15121762.

[3] Reavill C, Walther B, Stolerman IP, Testa B. Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology. 1990 Jul;29(7):619-24. PubMed PMID: 2385332.

[4] Raj H, Singh VK, Anand A, Paintal AS. Sensory origin of lobeline-induced sensations: a correlative study in man and cat. J Physiol. 1995 Jan 1;482 ( Pt 1):235-46. PubMed PMID: 7730986; PubMed Central PMCID: PMC1157767.

[5] Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA. Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. J Med Chem. 2005 Aug 25;48(17):5551-60. PubMed PMID: 16107155; PubMed Central PMCID: PMC3617589.

6: Marlin DJ, Roberts CA, Schroter RC, Lekeux P. Respiratory responses of mature horses to intravenous lobeline bolus. Equine Vet J. 2000 May;32(3):200-7. PubMed PMID: 10836474.7: Eyerman DJ, Yamamoto BK. Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum. J Pharmacol Exp Ther. 2005 Jan;312(1):160-9. Epub 2004 Aug 26. PubMed PMID: 15331654.8: Lim DY, Kim YS, Miwa S. Influence of lobeline on catecholamine release from the isolated perfused rat adrenal gland. Auton Neurosci. 2004 Jan 30;110(1):27-35. PubMed PMID: 14766322.9: Wang JJ, Liu SM, Chen R, Li L, Guo XS, Xue B, Hu WC. A novel effect of lobeline on vascular smooth muscle cell: inhibition of proliferation induced by endothelin-1. Pharmazie. 2007 Aug;62(8):620-4. PubMed PMID: 17867559.10: Ma Y, Wink M. Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells. Phytomedicine. 2008 Sep;15(9):754-8. doi: 10.1016/j.phymed.2007.11.028. Epub 2008 Jan 28. PubMed PMID: 18222670.1

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