143943-73-1|Lirequinil|(3s)-1-((10-Chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo(a)quinolizin-1-yl)carbonyl)-3-ethoxypyrrolidine.|-范德生物科技公司

Lirequinil

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names：
(3s)-1-((10-Chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo(a)quinolizin-1-yl)carbonyl)-3-ethoxypyrrolidine.
CAS号：
143943-73-1
MDL Number：
MF(分子式)： C26H25ClN2O3 MW(分子量)： 448.947
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Lirequinil
英文别名	Lirequinil; RO-413696; RO 413696; RO413696; Ro-41-3696; Ro 41-3696; Ro41-3696.
CAS号	143943-73-1
Inchi	InChI=1S/C26H25ClN2O3/c1-2-32-20-11-12-28(16-20)25(30)23-15-22(17-6-4-3-5-7-17)26(31)29-13-10-18-8-9-19(27)14-21(18)24(23)29/h3-9,14-15,20H,2,10-13,16H2,1H3/t20-/m0/s1
InchiKey	CBSWRAUYCIIUEI-FQEVSTJZSA-N
分子式 Formula	C26H25ClN2O3
分子量 Molecular Weight	448.947
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lirequinil(CAS:143943-73-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lirequinil, also known as RO-413696; Ro-41-3696, is GABA receptor agonist potentially for the treatment of sleep disorders. Ro 41-3696 acts more selectively than nitrazepam to promote the drowsy EEG pattern, and the partial agonistic properties may minimize the residual effects during waking mobility similar to the short-acting agent zopiclone.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Dingemanse J, Pedrazzetti E, van Giersbergen PL. Multiple-dose tolerability, pharmacodynamics, and pharmacokinetics of the quinolizinone hypnotic Ro 41-3696 in elderly subjects. Clin Neuropharmacol. 2001 Mar-Apr;24(2):82-90. PubMed PMID: 11307042.

[2]Dingemanse J, Bury M, Hussain Y, van Giersbergen P. Comparative tolerability, pharmacodynamics, and pharmacokinetics of a metabolite of a quinolizinone hypnotic and zolpidem in healthy subjects. Drug Metab Dispos. 2000 Dec;28(12):1411-6. PubMed PMID: 11095577.

[3] Dingemanse J, Bury M, Bock J, Joubert P. Comparative pharmacodynamics of Ro 41-3696, a new hypnotic, and zolpidem after night-time administration to healthy subjects. Psychopharmacology (Berl). 1995 Nov;122(2):169-74. PubMed PMID: 8848532.

[4] Dingemanse J, Bury M, Roncari G, Zell M, Gieschke R, Gaillard AW, Odink J, van Brummelen P. Pharmacokinetics and pharmacodynamics of Ro 41-3696, a novel nonbenzodiazepine hypnotic. J Clin Pharmacol. 1995 Aug;35(8):821-9. PubMed PMID: 8522640.

[5] Tsuboi M, Tanaka Y, Himori N. Changes in mouse hippocampal EEG characteristics after oral administration of Ro 41-3696, nitrazepam, or zopiclone alone and in combination with ethanol. Pharmacology. 1994 Nov;49(5):278-85. PubMed PMID: 7862739.

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