86559-73-1|Lipid X|(2R,3S,4R,5R,6R)-3-hydroxy-2-(hydroxymethyl)-5-(3-hydroxytetradecanamido)-6-(phosphonooxy)tetrahydro-2H-pyran-4-yl 3-hydroxytetradecanoate|-范德生物科技公司

Lipid X

NMR下载 COA and HPLC MSDS下载
names：
(2R,3S,4R,5R,6R)-3-hydroxy-2-(hydroxymethyl)-5-(3-hydroxytetradecanamido)-6-(phosphonooxy)tetrahydro-2H-pyran-4-yl 3-hydroxytetradecanoate
CAS号：
86559-73-1
MDL Number：
MF(分子式)： C34H66NO12P MW(分子量)： 711.87
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lipid X
英文别名	Lipid X;
CAS号	86559-73-1
Inchi	InChI=1S/C34H66NO12P/c1-3-5-7-9-11-13-15-17-19-21-26(37)23-29(39)35-31-33(32(41)28(25-36)45-34(31)47-48(42,43)44)46-30(40)24-27(38)22-20-18-16-14-12-10-8-6-4-2/h26-28,31-34,36-38,41H,3-25H2,1-2H3,(H,35,39)(H2,42,43,44)/t26?,27?,28-,31-,32-,33-,34-/m1/s1
InchiKey	HEHQDWUWJVPREQ-JIMHHRIFSA-N
分子式 Formula	C34H66NO12P
分子量 Molecular Weight	711.87
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lipid X(CAS:86559-73-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lipid X is a monosaccharide precursor of E coli lipid A.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Danner RL, Joiner KA, Parrillo JE. Inhibition of endotoxin-induced priming of human neutrophils by lipid X and 3-Aza-lipid X. J Clin Invest. 1987 Sep;80(3):605-12. PubMed PMID: 3624479; PubMed Central PMCID: PMC442281.

[2]Golenbock DT, Ebert S, Will JA, Proctor RA. Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep. Antimicrob Agents Chemother. 1988 Jan;32(1):37-41. PubMed PMID: 3348611; PubMed Central PMCID: PMC172094.

[3] Brozek KA, Bulawa CE, Raetz CR. Biosynthesis of lipid A precursors in Escherichia coli. A membrane-bound enzyme that transfers a palmitoyl residue from a glycerophospholipid to lipid X. J Biol Chem. 1987 Apr 15;262(11):5170-9. PubMed PMID: 3549717.

[4] Golenbock DT, Will JA, Raetz CR, Proctor RA. Lipid X ameliorates pulmonary hypertension and protects sheep from death due to endotoxin. Infect Immun. 1987 Oct;55(10):2471-6. PubMed PMID: 3308707; PubMed Central PMCID: PMC260732.

[5] Romano M, Hawiger J. Interaction of endotoxic lipid A and lipid X with purified human platelet protein kinase C. J Biol Chem. 1990 Jan 25;265(3):1765-70. PubMed PMID: 2295655.

6: Lam C, Schütze E, Walzl H, Basalka E. Protection of mice against lethal endotoxemia by lipid X is mediated through inhibition of neutrophil function. Circ Shock. 1987;22(4):311-21. PubMed PMID: 2820606.7: Pohlman TH, Winn RK, Callahan KS, Maier RV, Harlan JM. A glycolipid precursor of bacterial lipopolysaccharide (lipid X) lacks activity against endothelial cells in vitro and is not toxic in vivo. J Surg Res. 1988 Aug;45(2):228-37. PubMed PMID: 3043110.8: Young HE, Zhao J, Barker JR, Guan Z, Valdivia RH, Zhou P. Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis. MBio. 2016 Mar 22;7(2):e00090. doi: 10.1128/mBio.00090-16. PubMed PMID: 27006461; PubMed Central PMCID: PMC4807358.9: Lipka G, Demel RA, Hauser H. Phase behaviour of lipid X. Chem Phys Lipids. 1988 Oct;48(3-4):267-80. PubMed PMID: 3242955.10: Burhop KE, Proctor RA, Helgerson RB, Raetz CH, Starling JR, Will JA. Pulmonary pathophysiological changes in sheep caused by endotoxin precursor, lipid X. J Appl Physiol (1985). 1985 Dec;59(6):1726-32. PubMed PMID: 4077781.1

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