130565-83-2|Lifarizine methanesulfonate|1-benzhydryl-4-((5-methyl-2-(p-tolyl)-1H-imidazol-4-yl)methyl)piperazine methanesulfonate|-范德生物科技公司

Lifarizine methanesulfonate

NMR下载 COA and HPLC MSDS下载
names：
1-benzhydryl-4-((5-methyl-2-(p-tolyl)-1H-imidazol-4-yl)methyl)piperazine methanesulfonate
CAS号：
130565-83-2
MDL Number：
MF(分子式)： C30H36N4O3S MW(分子量)： 532.7
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	Lifarizine methanesulfonate
英文别名	Lifarizine methanesulfonate;
CAS号	130565-83-2
SMILES	CC1=C(CN2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)N=C(C5=CC=C(C)C=C5)N1.CS(=O)(O)=O
Inchi	InChI=1S/C29H32N4.CH4O3S/c1-22-13-15-26(16-14-22)29-30-23(2)27(31-29)21-32-17-19-33(20-18-32)28(24-9-5-3-6-10-24)25-11-7-4-8-12-25;1-5(2,3)4/h3-16,28H,17-21H2,1-2H3,(H,30,31);1H3,(H,2,3,4)
InchiKey	CGPIUYHUELMXMK-UHFFFAOYSA-N
分子式 Formula	C30H36N4O3S
分子量 Molecular Weight	532.7
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lifarizine methanesulfonate(CAS:130565-83-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lifarizine methanesulfonate is a sodium-calcium channel modulator that reduces ischemic brain damage.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Brown NA, Kemp JA, Seabrook GR. Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine. Br J Pharmacol. 1994 Oct;113(2):600-6. PubMed PMID: 7834213; PubMed Central PMCID: PMC1510106.

[2]Budd DC, May GR, Nicholls DG, McCormack JG. Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones. Br J Pharmacol. 1996 May;118(1):162-6. PubMed PMID: 8733590; PubMed Central PMCID: PMC1909495.

[3] MacKinnon AC, Wyatt KM, McGivern JG, Sheridan RD, Brown CM. [3H]-lifarizine, a high affinity probe for inactivated sodium channels. Br J Pharmacol. 1995 Jul;115(6):1103-9. PubMed PMID: 7582509; PubMed Central PMCID: PMC1908993.

[4] McBean DE, Winters V, Wilson AD, Oswald CB, Alps BJ, Armstrong JM. Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion. Br J Pharmacol. 1995 Dec;116(8):3093-8. PubMed PMID: 8719782; PubMed Central PMCID: PMC1909165.

[5] May GR, Rowand WS, McCormack JG, Sheridan RD. Neuroprotective profile of lifarizine (RS-87476) in rat cerebrocortical neurones in culture. Br J Pharmacol. 1995 Apr;114(7):1365-70. PubMed PMID: 7606340; PubMed Central PMCID: PMC1510289.

6: McGivern JG, Patmore L, Sheridan RD. Actions of the novel neuroprotective agent, lifarizine (RS-87476), on voltage-dependent sodium currents in the neuroblastoma cell line, N1E-115. Br J Pharmacol. 1995 Apr;114(8):1738-44. PubMed PMID: 7599943; PubMed Central PMCID: PMC1510400.7: Alps BJ, Calder C, Wilson AD, McBean DE, Armstrong JM. Reduction by lifarizine of the neuronal damage induced by cerebral ischaemia in rodents. Br J Pharmacol. 1995 Aug;115(8):1439-46. PubMed PMID: 8564203; PubMed Central PMCID: PMC1908890.8: Brown CM, Calder C, Linton C, Small C, Kenny BA, Spedding M, Patmore L. Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia. Br J Pharmacol. 1995 Aug;115(8):1425-32. PubMed PMID: 8564201; PubMed Central PMCID: PMC1908884.9: Sheridan RD. Selectivity of the neuroprotective agent lifarizine. Trends Pharmacol Sci. 1995 Sep;16(9):292. PubMed PMID: 7482992.10: Brown CM, Calder C, Alps BJ, Spedding M. The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil. Br J Pharmacol. 1993 May;109(1):175-7. PubMed PMID: 8388296; PubMed Central PMCID: PMC2175597.1

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开