119514-66-8|Lifarizine|1-(Diphenylmethyl)-4-((5-methyl-2-p-tolylimidazol-4-yl)methyl)piperazine|-范德生物科技公司

Lifarizine

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names：
1-(Diphenylmethyl)-4-((5-methyl-2-p-tolylimidazol-4-yl)methyl)piperazine
CAS号：
119514-66-8
MDL Number：
MF(分子式)： C29H32N4 MW(分子量)： 436.603
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lifarizine
英文别名	Lifarizine; RS-87476; RS 87476; RS87476; RS 87476-000; RS-87476-000.
CAS号	119514-66-8
Inchi	InChI=1S/C29H32N4/c1-22-13-15-26(16-14-22)29-30-23(2)27(31-29)21-32-17-19-33(20-18-32)28(24-9-5-3-6-10-24)25-11-7-4-8-12-25/h3-16,28H,17-21H2,1-2H3,(H,30,31)
InchiKey	HTDFEXRUDGWNHA-UHFFFAOYSA-N
分子式 Formula	C29H32N4
分子量 Molecular Weight	436.603
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lifarizine(CAS:119514-66-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lifarizine, also known as RS-87476, is a calcium and sodium channel antagonist potentially for the treatment of stroke. Lifarizine (RS-87476) showed neuroprotective efficacy in a simplified rat survival model of 2 vessel occlusion. The effects of lifarizine on intracellular Ca2+ and glutamate exocytosis may contribute to its neuroprotective action.
Application1
Application2
Application3

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备注

[1]Spedding M. Reasons why stroke trials underestimate the neuroprotective effects of drugs. Stroke. 2002 Jan;33(1):324-5. PubMed PMID: 11779937.

[2]Mestre M, Djellas Y, Carriot T, Cavero I. Frequency-independent blockade of cardiac Na+ channels by riluzole: comparison with established anticonvulsants and class I anti-arrhythmics. Fundam Clin Pharmacol. 2000 Mar-Apr;14(2):107-17. PubMed PMID: 10796057.

[3] Cramer WC, Toorop GP. Focal cerebral ischemia in the mouse: hypothermia and rapid screening of drugs. Gen Pharmacol. 1998 Feb;30(2):195-200. PubMed PMID: 9502174.

[4] Lees KR. Cerestat and other NMDA antagonists in ischemic stroke. Neurology. 1997 Nov;49(5 Suppl 4):S66-9. Review. PubMed PMID: 9371155.

[5] Deffois A, Fage D, Carter C. Inhibition of synaptosomal veratridine-induced sodium influx by antidepressants and neuroleptics used in chronic pain. Neurosci Lett. 1996 Dec 13;220(2):117-20. PubMed PMID: 8981487.

6: Budd DC, May GR, Nicholls DG, McCormack JG. Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones. Br J Pharmacol. 1996 May;118(1):162-6. PubMed PMID: 8733590; PubMed Central PMCID: PMC1909495.7: McBean DE, Winters V, Wilson AD, Oswald CB, Alps BJ, Armstrong JM. Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion. Br J Pharmacol. 1995 Dec;116(8):3093-8. PubMed PMID: 8719782; PubMed Central PMCID: PMC1909165.8: Squire IB, Lees KR, Pryse-Phillips W, Kertesz A, Bamford J. Efficacy and tolerability of lifarizine in acute ischemic stroke. A pilot study. Lifarizine Study Group. Ann N Y Acad Sci. 1995 Sep 15;76

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