91712-41-3|Levuglandin E2|(5Z,8R,9R,10E,12S)-8-acetyl-9-formyl-12-hydroxyheptadeca-5,10-dienoic acid|-范德生物科技公司

Levuglandin E2

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names：
(5Z,8R,9R,10E,12S)-8-acetyl-9-formyl-12-hydroxyheptadeca-5,10-dienoic acid
CAS号：
91712-41-3
MDL Number：
MF(分子式)： C20H32O5 MW(分子量)： 352.47
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Levuglandin E2
英文别名	Levuglandin E2;
CAS号	91712-41-3
SMILES	CCCCC[C@H](O)/C=C/[C@@H](C=O)[C@H](C(C)=O)C/C=C\CCCC(O)=O
Inchi	InChI=1S/C20H32O5/c1-3-4-7-10-18(23)14-13-17(15-21)19(16(2)22)11-8-5-6-9-12-20(24)25/h5,8,13-15,17-19,23H,3-4,6-7,9-12H2,1-2H3,(H,24,25)/b8-5-,14-13+/t17-,18-,19-/m0/s1
InchiKey	WJWAORNTZNRHBP-QNUMDXCLSA-N
分子式 Formula	C20H32O5
分子量 Molecular Weight	352.47
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Levuglandin E2(CAS:91712-41-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide; gamma-ketoaldehyde cpd; related to prostaglandin E2.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Iyer RS, Ghosh S, Salomon RG. Levuglandin E2 crosslinks proteins. Prostaglandins. 1989 Apr;37(4):471-80. PubMed PMID: 2762557.

[2]Murthi KK, Salomon RG, Sternlicht H. Levuglandin E2 inhibits mitosis and microtubule assembly. Prostaglandins. 1990 Jun;39(6):611-22. PubMed PMID: 2115185.

[3] Hoppe G, Subbanagounder G, O'Neil J, Salomon RG, Hoff HF. Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid. Biochim Biophys Acta. 1997 Jan 7;1344(1):1-5. PubMed PMID: 9022751.

[4] Salomon RG, Jirousek MR, Ghosh S, Sharma RB. Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins. Prostaglandins. 1987 Nov;34(5):643-56. PubMed PMID: 3481092.

[5] Jirousek MR, Murthi KK, Salomon RG. Electrophilic levuglandin E2-protein adducts bind glycine: a model for protein crosslinking. Prostaglandins. 1990 Aug;40(2):187-203. PubMed PMID: 2217833.

6: Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA. Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. Biochemistry. 2014 Apr 22;53(15):2436-41. doi: 10.1021/bi401673b. Epub 2014 Apr 11. PubMed PMID: 24684440; PubMed Central PMCID: PMC4004227.7: DiFranco E, Subbanagounder G, Kim S, Murthi K, Taneda S, Monnier VM, Salomon RG. Formation and stability of pyrrole adducts in the reaction of levuglandin E2 with proteins. Chem Res Toxicol. 1995 Jan-Feb;8(1):61-7. PubMed PMID: 7703368.8: Murthi KK, Friedman LR, Oleinick NL, Salomon RG. Formation of DNA-protein cross-links in mammalian cells by levuglandin E2. Biochemistry. 1993 Apr 20;32(15):4090-7. PubMed PMID: 8471616.9: Salomon RG, Sha W, Brame C, Kaur K, Subbanagounder G, O'Neil J, Hoff HF, Roberts LJ 2nd. Protein adducts of iso[4]levuglandin E2, a product of the isoprostane pathway, in oxidized low density lipoprotein. J Biol Chem. 1999 Jul 16;274(29):20271-80. PubMed PMID: 10400646.10: Salomon RG, Subbanagounder G, O'Neil J, Kaur K, Smith MA, Hoff HF, Perry G, Monnier VM. Levuglandin E2-protein adducts in human plasma and vasculature. Chem Res Toxicol. 1997 May;10(5):536-45. PubMed PMID: 9168251.1

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