1403-88-9|Levomycin|N,N'-(11,24-diisopropyl-2,4,12,15,17,25-hexamethyl-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane-7,20-diyl)bis(quinoxaline-2-carboxamide)|-范德生物科技公司

Levomycin

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names：
N,N'-(11,24-diisopropyl-2,4,12,15,17,25-hexamethyl-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane-7,20-diyl)bis(quinoxaline-2-carboxamide)
CAS号：
1403-88-9
MDL Number：
MF(分子式)： C51H64N12O12S2 MW(分子量)： 1101.26
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Levomycin
英文别名	Levomycin;
CAS号	1403-88-9
Inchi	InChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-77-51(40)76-11/h12-21,25-28,35-40,51H,22-24H2,1-11H3,(H,54,66)(H,55,67)(H,58,64)(H,59,65)
InchiKey	AUJXLBOHYWTPFV-UHFFFAOYSA-N
分子式 Formula	C51H64N12O12S2
分子量 Molecular Weight	1101.26
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Levomycin(CAS:1403-88-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Levomycin is a bioactive chemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H. RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening. J Antibiot (Tokyo). 2014 Apr;67(4):323-9. doi: 10.1038/ja.2013.144. Epub 2014 Feb 5. PubMed PMID: 24496142.

[3] Zhen X, Gong T, Liu F, Zhang PC, Zhou WQ, Li Y, Zhu P. A New Analogue of Echinomycin and a New Cyclic Dipeptide from a Marine-Derived Streptomyces sp. LS298. Mar Drugs. 2015 Nov 18;13(11):6947-61. doi: 10.3390/md13116947. PubMed PMID: 26593927; PubMed Central PMCID: PMC4663560.

[4] Hayase H, Watanabe N, Lim CL, Nogawa T, Komatsuya K, Kita K, Osada H. Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity. Biosci Biotechnol Biochem. 2015;79(4):633-5. doi: 10.1080/09168451.2014.987205. Epub 2014 Dec 4. PubMed PMID: 25471083.

[5] Singh V, Nand A, Chen C, Li Z, Li SJ, Wang S, Yang M, Merino A, Zhang L, Zhu J. Echinomycin, a potential binder of FKBP12, shows minor effect on calcineurin activity. J Biomol Screen. 2014 Oct;19(9):1275-81. doi: 10.1177/1087057114544742. Epub 2014 Aug 1. PubMed PMID: 25085862.

6: Hotta K, Keegan RM, Ranganathan S, Fang M, Bibby J, Winn MD, Sato M, Lian M, Watanabe K, Rigden DJ, Kim CY. Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis. Angew Chem Int Ed Engl. 2014 Jan 13;53(3):824-8. PubMed PMID: 24302672.7: Sato M, Nakazawa T, Tsunematsu Y, Hotta K, Watanabe K. Echinomycin biosynthesis. Curr Opin Chem Biol. 2013 Aug;17(4):537-45. doi: 10.1016/j.cbpa.2013.06.022. Epub 2013 Jul 12. Review. PubMed PMID: 23856054.8: Kambayashi S, Igase M, Kobayashi K, Kimura A, Shimokawa Miyama T, Baba K, Noguchi S, Mizuno T, Okuda M. Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015 Nov;77(11):1405-12. doi: 10.1292/jvms.15-0258. Epub 2015 Jun 6. PubMed PMID: 26050843; PubMed Central PMCID: PMC4667657.9: Ponnurangam S, Dandawate PR, Dhar A, Tawfik OW, Parab RR, Mishra PD, Ranadive P, Sharma R, Mahajan G, Umar S, Weir SJ, Sugumar A, Jensen RA, Padhye SB, Balakrishnan A, Anant S, Subramaniam D. Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells. Oncotarget. 2016 Jan 19;7(3):3217-32. doi: 10.18632/oncotarget.6560. PubMed PMID: 26673007; PubMed Central PMCID: PMC4823101.10: Trimmel K, Cvikl B, Müller HD, Nürnberger S, Gruber R, Moritz A, Agis H. L-mimosine increases the production of vascular endothelial growth factor in human tooth slice organ culture model. Int Endod J. 2015 Mar;48(3):252-60. doi: 10.1111/iej.12307. Epub 2014 Jun 28. PubMed PMID: 24786562.1

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