82570-34-1|Lemnalol|(1R,2S,4R,6S,7R,8S)-8-isopropyl-1-methyl-3-methylenetricyclo[4.4.0.02,7]decan-4-ol|-范德生物科技公司

Lemnalol

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names：
(1R,2S,4R,6S,7R,8S)-8-isopropyl-1-methyl-3-methylenetricyclo[4.4.0.02,7]decan-4-ol
CAS号：
82570-34-1
MDL Number：
MF(分子式)： C15H24O MW(分子量)： 220.35
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lemnalol
英文别名	Lemnalol;
CAS号	82570-34-1
SMILES	C=C1[C@H](O)C[C@@H]2[C@@]3(C)CC[C@@H](C(C)C)[C@H]2[C@H]13
Inchi	InChI=1S/C15H24O/c1-8(2)10-5-6-15(4)11-7-12(16)9(3)14(15)13(10)11/h8,10-14,16H,3,5-7H2,1-2,4H3/t10-,11-,12+,13+,14-,15+/m0/s1
InchiKey	LPXOPRGPLUWGKB-JRULLXGZSA-N
分子式 Formula	C15H24O
分子量 Molecular Weight	220.35
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Lemnalol(CAS:82570-34-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Lemnalol is a natural marine compound isolated from the Formosan soft coral Lemnalia cervicorni. Lemnalol produced anti-inflammatory and analgesic effects in carrageenan-injected rats.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lee HP, Lin YY, Duh CY, Huang SY, Wang HM, Wu SF, Lin SC, Jean YH, Wen ZH. Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model. J Pharm Pharmacol. 2015 Feb;67(2):274-85. doi: 10.1111/jphp.1233[1]Epub 2014 Dec 3[1]PubMed PMID: 25557511.

[2]Lee HP, Huang SY, Lin YY, Wang HM, Jean YH, Wu SF, Duh CY, Wen ZH. Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression. Mar Drugs. 2013 Jan 10;11(1):99-113. doi: 10.3390/md11010099. PubMed PMID: 23306170; PubMed Central PMCID: PMC3564160.

[3] Lin YC, Huang SY, Jean YH, Chen WF, Sung CS, Kao ES, Wang HM, Chakraborty C, Duh CY, Wen ZH. Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats. Behav Pharmacol. 2011 Dec;22(8):739-50. doi: 10.1097/FBP.0b013e32834d0ecb. PubMed PMID: 22067479.

[4] Jean YH, Chen WF, Duh CY, Huang SY, Hsu CH, Lin CS, Sung CS, Chen IM, Wen ZH. Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni. Eur J Pharmacol. 2008 Jan 14;578(2-3):323-31. Epub 2007 Sep 20. PubMed PMID: 17916350.

[5] Kikuchi H, Manda T, Kobayashi K, Yamada Y, Iguchi K. Anti-tumor activity of lemnalol isolated from the soft coral Lemnalia tenuis Verseveldt. Chem Pharm Bull (Tokyo). 1983 Mar;31(3):1086-8. PubMed PMID: 6136342.

6: Cheng SY, Lin EH, Huang JS, Wen ZH, Duh CY. Ylangene-type and nardosinane-type sesquiterpenoids from the soft corals Lemnalia flava and Paralemnalia thyrsoides. Chem Pharm Bull (Tokyo). 2010 Mar;58(3):381-5. PubMed PMID: 20190445.7: Duh CY, El-Gamal AA, Song PY, Wang SK, Dai CF. Steroids and sesquiterpenoids from the soft corals Dendronephthya gigantea and Lemnalia cervicorni. J Nat Prod. 2004 Oct;67(10):1650-3. PubMed PMID: 15497934.

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