188400-51-3|L-775,606|3-[3-[4-[2-(3-fluorophenyl)ethyl]piperazin-1-yl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole|-范德生物科技公司

L-775,606

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names：
3-[3-[4-[2-(3-fluorophenyl)ethyl]piperazin-1-yl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
CAS号：
188400-51-3
MDL Number：
MF(分子式)： C25H29FN6 MW(分子量)： 432.55
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L-775,606
英文别名	L-775,606; L 775,606; L775,606.
CAS号	188400-51-3
Inchi	InChI=1S/C25H29FN6/c26-22-5-1-3-20(15-22)8-10-31-13-11-30(12-14-31)9-2-4-21-17-27-25-7-6-23(16-24(21)25)32-18-28-29-19-32/h1,3,5-7,15-19,27H,2,4,8-14H2
InchiKey	ZUTQCPBDRJBADG-UHFFFAOYSA-N
分子式 Formula	C25H29FN6
分子量 Molecular Weight	432.55
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L-775,606(CAS:188400-51-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L-775,606 is a selective 5-hydroxytryptamine 1D agonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Watt AP, Pike A, Morrison D. Determination of the collisionally activated dissociation of a substituted indole by orthogonal acceleration quadrupole time-of-flight mass spectrometry. J Am Soc Mass Spectrom. 2001 Nov;12(11):1145-52. PubMed PMID: 11720388.

[2]Locker KL, Morrison D, Watt AP. Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001 Jan 5;750(1):13-23. PubMed PMID: 11204213.

[3] Longmore J, Maguire JJ, MacLeod A, Street L, Schofield WN, Hill RG. Comparison of the vasoconstrictor effects of the selective 5-HT1D-receptor agonist L-775,606 with the mixed 5-HT1B/1D-receptor agonist sumatriptan and 5-HT in human isolated coronary artery. Br J Clin Pharmacol. 2000 Feb;49(2):126-31. PubMed PMID: 10671906; PubMed Central PMCID: PMC2014896.

[4] Prueksaritanont T, Lu P, Gorham L, Sternfeld F, Vyas KP. Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist. Xenobiotica. 2000 Jan;30(1):47-59. PubMed PMID: 10659950.

[5] Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM. 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. J Med Chem. 1999 Feb 25;42(4):691-705. PubMed PMID: 10052976.

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