133240-46-7|L 158809|3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine|-范德生物科技公司

L 158809

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names：
3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
CAS号：
133240-46-7
MDL Number：
MF(分子式)： C24H23N7 MW(分子量)： 409.49
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK17009-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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询价

中文别名	L 158809
英文别名	L 158809; L-158809; L158809; L-158,809;
CAS号	133240-46-7
Inchi	InChI=1S/C24H23N7/c1-4-21-26-22-15(2)13-16(3)25-24(22)31(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-13H,4,14H2,1-3H3,(H,27,28,29,30)
InchiKey	YFWXFHNZGKNDBC-UHFFFAOYSA-N
分子式 Formula	C24H23N7
分子量 Molecular Weight	409.49
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 158809(CAS:133240-46-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 158809 is an angiotensin II type 1 receptor antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Saez F, Reverte V, Paliege A, Moreno JM, Llinás MT, Bachmann S, Salazar FJ. Sex-dependent hypertension and renal changes in aged rats with altered renal development. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F461-70. doi: 10.1152/ajprenal.00198.2014. Epub 2014 Jun 18. PubMed PMID: 24944267.

[2]Kitada K, Yui N, Mori T, Ohkita M, Matsumura Y. Vasoprotective effects of an endothelin receptor antagonist in ovariectomized female rats. Life Sci. 2014 Nov 24;118(2):379-85. doi: 10.1016/j.lfs.2014.01.009. Epub 2014 Jan 24. PubMed PMID: 24468711.

[3] Moore ED, Kooshki M, Wheeler KT, Metheny-Barlow LJ, Robbins ME. Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiat Res. 2014 Jan;181(1):21-32. doi: 10.1667/RR13475.1. Epub 2013 Dec 30. PubMed PMID: 24377717; PubMed Central PMCID: PMC4118588.

[4] Meinen S, Lin S, Ruegg MA. Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A). Skelet Muscle. 2012 Sep 3;2(1):18. doi: 10.1186/2044-5040-2-18. PubMed PMID: 22943509; PubMed Central PMCID: PMC3598380.

[5] Camelo JS Jr, Martins AR, Rosa E, Ramos SG, Hehre D, Bancalari E, Suguihara C. Angiotensin II type 1 receptor blockade partially attenuates hypoxia-induced pulmonary hypertension in newborn piglets: relationship with the nitrergic system. Braz J Med Biol Res. 2012 Feb;45(2):163-71. Epub 2012 Feb 9. PubMed PMID: 22310488; PubMed Central PMCID: PMC3854258.

6: Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011 Jul 14;43(13):829-35. doi: 10.1152/physiolgenomics.00167.2010. Epub 2011 May 3. PubMed PMID: 21540301; PubMed Central PMCID: PMC3132839.7: Chitravanshi VC, Sapru HN. Cardiovascular responses elicited by a new endogenous angiotensin in the nucleus tractus solitarius of the rat. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H230-40. doi: 10.1152/ajpheart.00861.2010. Epub 2010 Nov 12. PubMed PMID: 21076017; PubMed Central PMCID: PMC3023243.8: Conner KR, Payne VS, Forbes ME, Robbins ME, Riddle DR. Effects of the AT1 receptor antagonist L-158,809 on microglia and neurogenesis after fractionated whole-brain irradiation. Radiat Res. 2010 Jan;173(1):49-61. doi: 10.1667/RR1821.1. PubMed PMID: 20041759; PubMed Central PMCID: PMC2811039.9: Oruc N, Ozutemiz O, Nart D, Yuce G, Celik HA, Ilter T. Inhibition of renin-angiotensin system in experimental acute pancreatitis in rats: a new therapeutic target? Exp Toxicol Pathol. 2010 Jul;62(4):353-60. doi: 10.1016/j.etp.2009.05.001. Epub 2009 Jun 13. PubMed PMID: 19525099.10: Kvochina L, Hasser EM, Heesch CM. Pregnancy decreases GABAergic inhibition of the hypothalamic paraventricular nucleus. Physiol Behav. 2009 May 25;97(2):171-9. doi: 10.1016/j.physbeh.2009.02.018. Epub 2009 Feb 28. PubMed PMID: 19254733; PubMed Central PMCID: PMC3906727.1

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