133240-46-7|L 158809|3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine|-范德生物科技公司

L 158809

NMR下载 COA and HPLC MSDS下载
names：
3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine
CAS号：
133240-46-7
MDL Number：
MF(分子式)： C24H23N7 MW(分子量)： 409.49
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
FMK17009-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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询价

中文别名	L 158809
英文别名	L 158809; L-158809; L158809; L-158,809;
CAS号	133240-46-7
SMILES	CC1=C2C(N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(CC)=N2)=NC(C)=C1
Inchi	InChI=1S/C24H23N7/c1-4-21-26-22-15(2)13-16(3)25-24(22)31(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-13H,4,14H2,1-3H3,(H,27,28,29,30)
InchiKey	YFWXFHNZGKNDBC-UHFFFAOYSA-N
分子式 Formula	C24H23N7
分子量 Molecular Weight	409.49
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 158809(CAS:133240-46-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 158809 is an angiotensin II type 1 receptor antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Saez F, Reverte V, Paliege A, Moreno JM, Llinás MT, Bachmann S, Salazar FJ. Sex-dependent hypertension and renal changes in aged rats with altered renal development. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F461-70. doi: 10.1152/ajprenal.00198.2014. Epub 2014 Jun 18. PubMed PMID: 24944267.

[2]Kitada K, Yui N, Mori T, Ohkita M, Matsumura Y. Vasoprotective effects of an endothelin receptor antagonist in ovariectomized female rats. Life Sci. 2014 Nov 24;118(2):379-85. doi: 10.1016/j.lfs.2014.01.009. Epub 2014 Jan 24. PubMed PMID: 24468711.

[3] Moore ED, Kooshki M, Wheeler KT, Metheny-Barlow LJ, Robbins ME. Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiat Res. 2014 Jan;181(1):21-32. doi: 10.1667/RR13475.1. Epub 2013 Dec 30. PubMed PMID: 24377717; PubMed Central PMCID: PMC4118588.

[4] Meinen S, Lin S, Ruegg MA. Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A). Skelet Muscle. 2012 Sep 3;2(1):18. doi: 10.1186/2044-5040-2-18. PubMed PMID: 22943509; PubMed Central PMCID: PMC3598380.

[5] Camelo JS Jr, Martins AR, Rosa E, Ramos SG, Hehre D, Bancalari E, Suguihara C. Angiotensin II type 1 receptor blockade partially attenuates hypoxia-induced pulmonary hypertension in newborn piglets: relationship with the nitrergic system. Braz J Med Biol Res. 2012 Feb;45(2):163-71. Epub 2012 Feb 9. PubMed PMID: 22310488; PubMed Central PMCID: PMC3854258.

6: Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011 Jul 14;43(13):829-35. doi: 10.1152/physiolgenomics.00167.2010. Epub 2011 May 3. PubMed PMID: 21540301; PubMed Central PMCID: PMC3132839.7: Chitravanshi VC, Sapru HN. Cardiovascular responses elicited by a new endogenous angiotensin in the nucleus tractus solitarius of the rat. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H230-40. doi: 10.1152/ajpheart.00861.2010. Epub 2010 Nov 12. PubMed PMID: 21076017; PubMed Central PMCID: PMC3023243.8: Conner KR, Payne VS, Forbes ME, Robbins ME, Riddle DR. Effects of the AT1 receptor antagonist L-158,809 on microglia and neurogenesis after fractionated whole-brain irradiation. Radiat Res. 2010 Jan;173(1):49-61. doi: 10.1667/RR1821.1. PubMed PMID: 20041759; PubMed Central PMCID: PMC2811039.9: Oruc N, Ozutemiz O, Nart D, Yuce G, Celik HA, Ilter T. Inhibition of renin-angiotensin system in experimental acute pancreatitis in rats: a new therapeutic target? Exp Toxicol Pathol. 2010 Jul;62(4):353-60. doi: 10.1016/j.etp.2009.05.001. Epub 2009 Jun 13. PubMed PMID: 19525099.10: Kvochina L, Hasser EM, Heesch CM. Pregnancy decreases GABAergic inhibition of the hypothalamic paraventricular nucleus. Physiol Behav. 2009 May 25;97(2):171-9. doi: 10.1016/j.physbeh.2009.02.018. Epub 2009 Feb 28. PubMed PMID: 19254733; PubMed Central PMCID: PMC3906727.1

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