220129-58-8|KUL-7211|2-(4-(2-(((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)amino)ethyl)phenoxy)acetic acid|-范德生物科技公司

KUL-7211

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names：
2-(4-(2-(((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)amino)ethyl)phenoxy)acetic acid
CAS号：
220129-58-8
MDL Number：
MF(分子式)： C19H23NO5 MW(分子量)： 345.395
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	KUL-7211
英文别名	KUL-7211; KUL 7211; KUL7211
CAS号	220129-58-8
Inchi	InChI=1S/C19H23NO5/c1-13(19(24)15-4-6-16(21)7-5-15)20-11-10-14-2-8-17(9-3-14)25-12-18(22)23/h2-9,13,19-21,24H,10-12H2,1H3,(H,22,23)/t13-,19-/m0/s1
InchiKey	KKXPBQQLKHBRDA-DJJJIMSYSA-N
分子式 Formula	C19H23NO5
分子量 Molecular Weight	345.395
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KUL-7211(CAS:220129-58-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KUL-7211 is an β2 and β3 adrenergic receptor agonist potentially for the treatment of pain and urinary tract stones. KUL-7211 is a potent ureteral relaxant with a relatively small hypotensive effect. KUL-7211 relaxed 80-mM-KCl-induced tonic contractions in both rabbit (pD(2) value 5.86 +/- 0.13, whose ureteral relaxation is mediated via beta(2)-adrenergic stimulation) and canine (pD(2) value 6.52 +/- 0.16, via beta(3)-adrenergic stimulation) isolated ureters in a concentration-dependent manner. KUL-7211 also reduced the spontaneous rhythmic contraction in a canine ureteral spiral preparation in a concentration-dependent manner, the pD(2) value being 6.83 +/- 0.20.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wanajo I, Tomiyama Y, Yamazaki Y, Kojima M. Ureteral selectivity of intravenous β-adrenoceptor agonists in pig model of acute ureteral obstruction: comparison of KUL-7211, a selective β2/β3 agonist, with isoproterenol, terbutaline, and CL-316243. Urology. 2011 May;77(5):1266.e1-6. doi: 10.1016/j.urology.2010.12.045. PubMed PMID: 21397304.

[2]Wanajo I, Tomiyama Y, Tadachi M, Kobayashi M, Yamazaki Y, Kojima M, Shibata N. The potency of KUL-7211, a selective ureteral relaxant, in isolated canine ureter: comparison with various spasmolytics. Urol Res. 2005 Dec;33(6):409-14. PubMed PMID: 16133579.

[3] Tomiyama Y, Murakami M, Hayakawa K, Akiyama K, Yamazaki Y, Kojima M, Shibata N, Akahane M. Pharmacological profile of KUL-7211, a selective beta-adrenoceptor agonist, in isolated ureteral smooth muscle. J Pharmacol Sci. 2003 Aug;92(4):411-9. PubMed PMID: 12939526.

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