105955-01-9|KS370G|3-(3,4-Dihydroxy-phenyl)-N-phenethyl-acrylamide|-范德生物科技公司

KS370G

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names：
3-(3,4-Dihydroxy-phenyl)-N-phenethyl-acrylamide
CAS号：
105955-01-9
MDL Number：
MF(分子式)： C17H17NO3 MW(分子量)： 283.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	KS370G
英文别名	KS370G; KS-370-G; KS 370 G;
CAS号	105955-01-9
Inchi	InChI=1S/C17H17NO3/c19-15-8-6-14(12-16(15)20)7-9-17(21)18-11-10-13-4-2-1-3-5-13/h1-9,12,19-20H,10-11H2,(H,18,21)/b9-7+
InchiKey	QOWABIXYAFJMQE-VQHVLOKHSA-N
分子式 Formula	C17H17NO3
分子量 Molecular Weight	283.32
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KS370G(CAS:105955-01-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. It acts by attenuating collagen deposition in the obstructed kidney and significantly lowering the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Chuang ST, Kuo YH, Su MJ. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7. doi: 10.1016/j.ejphar.2015.01.020. Epub 2015 Jan 22. PubMed PMID: 25620133.

[2]Chuang ST, Kuo YH, Su MJ. Antifibrotic effects of KS370G, a caffeamide derivative, in renal ischemia-reperfusion injured mice and renal tubular epithelial cells. Sci Rep. 2014 Jul 24;

4:5814. doi: 10.1038/srep05814. PubMed PMID: 25056456; PubMed Central PMCID: PMC4108915.

[4]Lu DY, Huang BR, Yeh WL, Lin HY, Huang SS, Liu YS, Kuo YH. Anti-neuroinflammatory effect of a novel caffeamide derivative, KS370G, in microglial cells. Mol Neurobiol. 2013 Dec;48(3):863-74. doi: 10.1007/s12035-013-8474-y. Epub 2013 Jun 26. PubMed PMID: 23801310.

[5] Weng YC, Chuang CF, Chuang ST, Chiu HL, Kuo YH, Su MJ. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur J Pharmacol. 2012 Jun 5;684(1-3):108-15. doi: 10.1016/j.ejphar.2012.03.029. Epub 2012 Mar 29. PubMed PMID: 22484506.

5: Weng YC, Chiu HL, Lin YC, Chi TC, Kuo YH, Su MJ. Antihyperglycemic effect of a caffeamide derivative, KS370G, in normal and diabetic mice. J Agric Food Chem. 2010 Sep 22;58(18):10033-8. doi: 10.1021/jf1024246. PubMed PMID: 20804127.

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