116430-80-9|Krds peptide|(S)-4-(((S)-1-carboxy-2-hydroxyethyl)amino)-3-((S)-2-((S)-2,6-diaminohexanamido)-5-guanidinopentanamido)-4-oxobutanoic acid|-范德生物科技公司

Krds peptide

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names：
(S)-4-(((S)-1-carboxy-2-hydroxyethyl)amino)-3-((S)-2-((S)-2,6-diaminohexanamido)-5-guanidinopentanamido)-4-oxobutanoic acid
CAS号：
116430-80-9
MDL Number：
MF(分子式)： C19H36N8O8 MW(分子量)： 504.54
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Krds peptide
英文别名	Krds peptide; Lys-arg-asp-ser;
CAS号	116430-80-9
Inchi	InChI=1S/C19H36N8O8/c20-6-2-1-4-10(21)15(31)25-11(5-3-7-24-19(22)23)16(32)26-12(8-14(29)30)17(33)27-13(9-28)18(34)35/h10-13,28H,1-9,20-21H2,(H,25,31)(H,26,32)(H,27,33)(H,29,30)(H,34,35)(H4,22,23,24)/t10-,11-,12-,13-/m0/s1
InchiKey	UIQDLWNRJRTKJV-CYDGBPFRSA-N
分子式 Formula	C19H36N8O8
分子量 Molecular Weight	504.54
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Krds peptide(CAS:116430-80-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Krds peptide is a synthetic tetrapeptide derived from lactotransferrin (residues 39 to 42); inhibits binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-Stimulated platelets and megakaryocytes.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lévy-Toledano S, Grelac F, Caen JP, Maclouf J. KRDS, a peptide derived from human lactotransferrin, inhibits thrombin-induced thromboxane synthesis by a cyclooxygenase-independent mechanism. Thromb Haemost. 1995 May;73(5):857-6[1]PubMed PMID: 7482416.

[2]Mazoyer E, Lévy-Toledano S, Rendu F, Hermant L, Lu H, Fiat AM, Jollès P, Caen J. KRDS, a new peptide derived from human lactotransferrin, inhibits platelet aggregation and release reaction. Eur J Biochem. 1990 Nov 26;194(1):43-9. PubMed PMID: 2174781.

[3] Wu G, Ruan C, Drouet L, Caen J. Inhibition effects of KRDS, a peptide derived from lactotransferrin, on platelet function and arterial thrombus formation in dogs. Haemostasis. 1992;22(1):1-6. PubMed PMID: 1381697.

[4] Drouet L, Bal dit Sollier C, Cisse M, Pignaud G, Mazoyer E, Fiat AM, Jolles P, Caen JP. The antithrombotic effect of KRDS, a lactotransferrin peptide, compared with RGDS. Nouv Rev Fr Hematol. 1990;32(1):59-62. PubMed PMID: 2349083.

[5] Raha S, Dosquet C, Abgrall JF, Jolles P, Fiat AM, Caen JP. KRDS--a tetrapeptide derived from lactotransferrin--inhibits binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-stimulated platelets and megakaryocytes. Blood. 1988 Jul;72(1):172-8. PubMed PMID: 3291978.

6: Kumar DA, Manikandan P, Sumitra M, Raju KV, Gayathri C, Arutselvan N, Puvanakrishnan R. A novel peptide derivative exhibits anti inflammatory and antioxidant activity in adjuvant induced arthritis in rats. Mol Cell Biochem. 2002 Jan;229(1-2):9-17. PubMed PMID: 11936851.7: Ahmed MR, Basha SH, Gopinath D, Muthusamy R, Jayakumar R. Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide-incorporated collagen tubes. J Peripher Nerv Syst. 2005 Mar;10(1):17-30. PubMed PMID: 15703015.8: Meddeb S, Demaret JP, Ballini JP, Fiat AM, Jollès P, Ptak M, Vigny P. A conformational study of Lys-Arg-Asp-Ser and analogs, a series of potent antithrombotic peptides. An approach based on simulated annealing and 1H NMR. J Biomol Struct Dyn. 1994 Apr;11(5):959-81. PubMed PMID: 7946066.9: Kumar DA, Settu K, Raju KV, Kumanan K, Manohar BM, Puvanakrishnan R. Inhibition of nitric oxide and caspase-3 mediated apoptosis by a tetrapeptide derivative (PEP1261) in cultured synovial fibroblasts from collagen-induced arthritis. Mol Cell Biochem. 2006 Jan;282(1-2):125-39. PubMed PMID: 16317520.10: Ramesh CV, Malarvannan P, Jayakumar R, Jayasundar S, Puvanakrishnan R. Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. Mol Cell Biochem. 1998 Oct;187(1-2):173-82. PubMed PMID: 9788755.

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