172489-10-0|KR-30450|(R)-1-(2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-chromen-4-yl)pyrrolidin-2-one|-范德生物科技公司

KR-30450

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names：
(R)-1-(2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-chromen-4-yl)pyrrolidin-2-one
CAS号：
172489-10-0
MDL Number：
MF(分子式)： C17H18N2O6 MW(分子量)： 346.339
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	KR-30450
英文别名	KR-30450; SKP-450; KR30450; SKP450; KR 30450; SKP 450
CAS号	172489-10-0
Inchi	InChI=1S/C17H18N2O6/c1-17(16-23-7-8-24-16)10-13(18-6-2-3-15(18)20)12-9-11(19(21)22)4-5-14(12)25-17/h4-5,9-10,16H,2-3,6-8H2,1H3/t17-/m1/s1
InchiKey	NJJPKIPOZSWUHV-QGZVFWFLSA-N
分子式 Formula	C17H18N2O6
分子量 Molecular Weight	346.339
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KR-30450(CAS:172489-10-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KR-30450 is potassium channel agonist potentially for the treatment of hypertension.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Jung YS, Moon CH, Cho TS, Yoo SE, Shin HS. Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts. Jpn J Pharmacol. 1998 Jan;76(1):65-73. PubMed PMID: 9517406.

[2]Kwak YG, Park SK, Kang HS, Kim JS, Chae SW, Cho KP, Yoo SE, Kim D. KR-30450, a newly synthesized benzopyran derivative, activates the cardiac ATP-sensitive K+ channel. J Pharmacol Exp Ther. 1995 Nov;275(2):807-12. PubMed PMID: 7473170.

[3] Kwan YW, To KW, Lau WM, Tsang SH. Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats. Eur J Pharmacol. 1999 Jan 22;365(2-3):241-51. PubMed PMID: 9988108.

[4] Shin HS, Seo HW, Oh JH, Lee BH. Antihypertensive effects of the novel potassium channel activator SKP-450 and its major metabolites in rats. Arzneimittelforschung. 1998 Oct;48(10):969-78. PubMed PMID: 9825113.

[5] Jang IJ, Yu KS, Shon JH, Bae KS, Cho JY, Yi SY, Shin SG, Ryu KH, Cho YB, Kim DK, Yoo SE. Pharmacokinetic/pharmacodynamic evaluation of a novel potassium channel opener, SKP-450, in healthy volunteers. J Clin Pharmacol. 2000 Jul;40(7):752-61. PubMed PMID: 10883417.

6: Kim HH, Yoo SE, Lee WS, Rhim BY, Hong KW. SKP-450 inhibits migration and DNA synthesis stimulated by oxidized low density lipoprotein in smooth muscle cells. Eur J Pharmacol. 1999 Nov 3;383(3):373-9. PubMed PMID: 10594331.7: Hong KW, Shin HS, Kim CD, Shin YW, Yoo Se. Pharmacological profiles of SKP-450 and its family, a K+ channel opener, in comparison with levcromakalim. Pharmacol Res. 1998 Sep;38(3):191-7. PubMed PMID: 9782069.8: Cheon HG, Kim HJ, Mo HK, Yoo SE, Lee BH. Anti-ulcer activity of SKP-450, a novel potassium channel activator, in rats. Pharmacol Res. 1999 Sep;40(3):243-8. PubMed PMID: 10479468.9: Baek M, Chung HS, Kim Y, Kim DH. Disposition and metabolism of 2-(2''(1'',3''-dioxolan-2-yl)-2- methyl-4-(2'-oxopyrrolidin-1-Yl)-6-nitro-2h-1-benzopyran (SKP-450) in rats. Drug Metab Dispos. 1999 Apr;27(4):510-6. PubMed PMID: 10101146.10: Lee EY, Lim DM, Yoo SE, Kim DK, Paik YK. Biochemical basis for a cholesterol-lowering activity of 2-[2"-(1",3"-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6- nitro-2H-1-benzopyran (SKP-450), a novel antihypertensive agent. Biochem Pharmacol. 1999 Mar 1;57(5):579-82. PubMed PMID: 9952322.1

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