139694-65-8|Kni 102|L-Prolinamide, N2-((phenylmethoxy)carbonyl)-L-asparaginyl-(2S,3S)-2-hydroxy-4-phenyl-3-aminobutanoyl-N-(1,1-dimethylethyl)-|-范德生物科技公司

Kni 102

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names：
L-Prolinamide, N2-((phenylmethoxy)carbonyl)-L-asparaginyl-(2S,3S)-2-hydroxy-4-phenyl-3-aminobutanoyl-N-(1,1-dimethylethyl)-
CAS号：
139694-65-8
MDL Number：
MF(分子式)： C31H41N5O7 MW(分子量)： 595.697
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Kni 102
英文别名	Kni 102; Kni-102; Kn102.
CAS号	139694-65-8
Inchi	InChI=1S/C31H41N5O7/c1-31(2,3)35-28(40)24-15-10-16-36(24)29(41)26(38)22(17-20-11-6-4-7-12-20)33-27(39)23(18-25(32)37)34-30(42)43-19-21-13-8-5-9-14-21/h4-9,11-14,22-24,26,38H,10,15-19H2,1-3H3,(H2,32,37)(H,33,39)(H,34,42)(H,35,40)/t22-,23-,24-,26-/m0/s1
InchiKey	XCVUOCMQYKSJJR-IGRGDXOOSA-N
分子式 Formula	C31H41N5O7
分子量 Molecular Weight	595.697
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Kni 102(CAS:139694-65-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Kni 102 is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Asagarasu A, Takayanagi N, Achiwa K. Synthesis of dipeptide-type human immunodeficiency virus (HIV) protease inhibitors with a binding unit to gp120. Chem Pharm Bull (Tokyo). 1998 May;46(5):867-70. PubMed PMID: 9621421.

[2]Asagarasu A, Uchiyama T, Achiwa K. Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120. Chem Pharm Bull (Tokyo). 1998 Apr;46(4):697-703. PubMed PMID: 9579045.

[3] Marastoni M, Fantin G, Bortolotti F, Tomatis R. Synthesis and activity of pseudotripeptide inhibitors of HIV-1 protease containing D(-)-O-(benzyl)tartaric acid. Arzneimittelforschung. 1996 Nov;46(11):1099-101. PubMed PMID: 8955873.

[4] el-Farrash MA, Kuroda MJ, Kitazaki T, Masuda T, Kato K, Hatanaka M, Harada S. Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor. J Virol. 1994 Jan;68(1):233-9. PubMed PMID: 8254733; PubMed Central PMCID: PMC236282.

[5] Kato R, Takahashi O, Kiso Y, Moriguchi I, Hirono S. Solution structure of HIV-1 protease-allophenylnorstatine derivative inhibitor complex obtained from molecular dynamics simulation. Chem Pharm Bull (Tokyo). 1994 Jan;42(1):176-8. PubMed PMID: 8124761.

6: Fujisawa Y, Kakinuma A. [HIV protease inhibitors]. Tanpakushitsu Kakusan Koso. 1993 Aug;38(11):2012-30. Review. Japanese. PubMed PMID: 8210441.7: Mimoto T, Imai J, Tanaka S, Hattori N, Kisanuki S, Akaji K, Kiso Y. KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic. Chem Pharm Bull (Tokyo). 1991 Nov;39(11):3088-90. PubMed PMID: 1799953.

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