819868-62-7|KL-1156|6-Hydroxy-7-methoxy-N-phenyl-3,4-dihydro-2H-chromene-2-carboxamide|-范德生物科技公司

KL-1156

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names：
6-Hydroxy-7-methoxy-N-phenyl-3,4-dihydro-2H-chromene-2-carboxamide
CAS号：
819868-62-7
MDL Number：
MF(分子式)： C17H17NO4 MW(分子量)： 299.32
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	KL-1156
英文别名	KL-1156; KL 1156; KL1156;
CAS号	819868-62-7
SMILES	O=C(C1CCC2=C(O1)C=C(OC)C(O)=C2)NC3=CC=CC=C3
Inchi	InChI=1S/C17H17NO4/c1-21-16-10-15-11(9-13(16)19)7-8-14(22-15)17(20)18-12-5-3-2-4-6-12/h2-6,9-10,14,19H,7-8H2,1H3,(H,18,20)
InchiKey	JXCMRGWJFGLXJJ-UHFFFAOYSA-N
分子式 Formula	C17H17NO4
分子量 Molecular Weight	299.32
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	KL-1156(CAS:819868-62-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	KL-1156 is a NF-κB inhibitor and lipopolysaccharide (LPS)-induced nitric oxide production inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Choi M, Jo H, Park HJ, Sateesh Kumar A, Lee J, Yun J, Kim Y, Han SB, Jung JK, Cho J, Lee K, Kwak JH, Lee H. Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-κB. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2545-9. doi: 10.1016/j.bmcl.2015.04.050. Epub 2015 Apr 23. PubMed PMID: 25953156.

[2]Choi M, Hwang YS, Kumar AS, Jo H, Jeong Y, Oh Y, Lee J, Yun J, Kim Y, Han SB, Jung JK, Cho J, Lee H. Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2404-7. doi: 10.1016/j.bmcl.2014.04.053. Epub 2014 Apr 20. PubMed PMID: 24792464.

[3] Kwak JH, Won SW, Kim TJ, Yi W, Choi EH, Kim SC, Park H, Roh E, Jung JK, Hwang BY, Hong JT, Kim Y, Cho J, Lee H. Synthesis and nuclear factor-kappaB inhibitory activities of 6- or 7-methylchroman-2-carboxylic acid N-(substituted) phenylamides. Arch Pharm Res. 2009 Feb;32(2):167-75. doi: 10.1007/s12272-009-1131-3. Epub 2009 Mar 13. PubMed PMID: 19280144.

[4] Kwak JH, Won SW, Kim TJ, Roh E, Kang HY, Lee HW, Jung JK, Hwang BY, Kim Y, Cho J, Lee H. Synthesis of chroman-2-carboxylic acid N-(substituted)phenylamides and their inhibitory effect on nuclear factor-kappaB (NF-kappaB) activation. Arch Pharm Res. 2008 Feb;31(2):133-41. PubMed PMID: 18365680.

[5] Kwak JH, Kim BH, Jung JK, Kim Y, Cho J, Lee H. Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation. Arch Pharm Res. 2007 Oct;30(10):1210-5. PubMed PMID: 18038899.

6: Rak Min K, Lee H, Hak Kim B, Chung E, Min Cho S, Kim Y. Inhibitory effect of 6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide on nitric oxide and interleukin-6 production in macrophages. Life Sci. 2005 Nov 4;77(25):3242-57. Epub 2005 Jun 22. PubMed PMID: 15978634.7: Kim BH, Reddy AM, Lee KH, Chung EY, Cho SM, Lee H, Min KR, Kim Y. Inhibitory mechanism of chroman compound on LPS-induced nitric oxide production and nuclear factor-kappaB activation. Biochem Biophys Res Commun. 2004 Dec 3;325(1):223-8. PubMed PMID: 15522222.

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