35303-13-0|Kinamycin B|5H-Benzo(b)carbazole-5-carbonitrile, 3-(acetyloxy)-1,2,3,4,6,11-hexahydro- 1,2,4,7-tetrahydroxy-3-methyl-6,11-dioxo-|-范德生物科技公司

Kinamycin B

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names：
5H-Benzo(b)carbazole-5-carbonitrile, 3-(acetyloxy)-1,2,3,4,6,11-hexahydro- 1,2,4,7-tetrahydroxy-3-methyl-6,11-dioxo-
CAS号：
35303-13-0
MDL Number：
MF(分子式)： C20H16N2O8 MW(分子量)： 412.35
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Kinamycin B
英文别名	Kinamycin B; Kinamycin-B; KinamycinB;
CAS号	35303-13-0
Inchi	InChI=1S/C20H16N2O8/c1-7(23)30-20(2)18(28)14-12(17(27)19(20)29)11-13(22(14)6-21)16(26)10-8(15(11)25)4-3-5-9(10)24/h3-5,17-19,24,27-29H,1-2H3
InchiKey	VTBQTYQHTVTELM-UHFFFAOYSA-N
分子式 Formula	C20H16N2O8
分子量 Molecular Weight	412.35
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Kinamycin B(CAS:35303-13-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Kinamycin B is an antibacterial agent that is used for anticancer purposes.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Wang B, Ren J, Li L, Guo F, Pan G, Ai G, Aigle B, Fan K, Yang K. Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction. Chem Commun (Camb). 2015 May 25;51(42):8845-8. doi: 10.1039/c5cc01986a. PubMed PMID: 25920893.

[2]Woo CM, Gholap SL, Lu L, Kaneko M, Li Z, Ravikumar PC, Herzon SB. Development of enantioselective synthetic routes to (-)-kinamycin F and (-)-lomaiviticin aglycon. J Am Chem Soc. 2012 Oct 17;134(41):17262-73. doi: 10.1021/ja307497h. Epub 2012 Oct 3. PubMed PMID: 23030272; PubMed Central PMCID: PMC3505684.

[3] Gould SJ, Melville CR, Cone MC, Chen J, Carney JR. Kinamycin Biosynthesis. Synthesis, Isolation, and Incorporation of Stealthin C, an Aminobenzo[b]fluorene. J Org Chem. 1997 Jan 24;62(2):320-324. PubMed PMID: 11671405.

[4] Kumamoto T. [Synthetic studies on kinamycin antibiotics]. Yakugaku Zasshi. 2010 Nov;130(11):1535-41. Review. Japanese. PubMed PMID: 21048414.

[5] Omura S, Nakagawa A, Yamada H, Hata T, Furusaki A. Structures and biological properties of Kinamycin A, B, C, and D. Chem Pharm Bull (Tokyo). 1973 May;21(5):931-40. PubMed PMID: 4727361.

6: Seaton PJ, Gould SJ. New products related to kinamycin from Streptomyces murayamaensis. II. Structures of pre-kinamycin, keto-anhydrokinamycin, and kinamycins E and F. J Antibiot (Tokyo). 1989 Feb;42(2):189-97. PubMed PMID: 2925510.7: Hasinoff BB, Wu X, Yalowich JC, Goodfellow V, Laufer RS, Adedayo O, Dmitrienko GI. Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects. Anticancer Drugs. 2006 Aug;17(7):825-37. PubMed PMID: 16926632.8: Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB. The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA. Nat Chem. 2014 Jun;6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 11. PubMed PMID: 24848236; PubMed Central PMCID: PMC4090708.9: Woo CM, Gholap SL, Herzon SB. Insights into lomaiviticin biosynthesis. Isolation and structure elucidation of (-)-homoseongomycin. J Nat Prod. 2013 Jul 26;76(7):1238-41. doi: 10.1021/np400355h. Epub 2013 Jun 26. PubMed PMID: 23803003.10: Zeng W, Eric Ballard T, Tkachenko AG, Burns VA, Feldheim DL, Melander C. Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5148-51. Epub 2006 Jul 25. PubMed PMID: 16870443.1

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