5532-23-0|Jacozine|(2S,3S,6'R,9a1'R,14a'R)-6'-hydroxy-3,6'-dimethyl-5'-methylene-5',6',9',9a1',11',13',14',14a'-octahydro-2'H-spiro[oxirane-2,3'-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine]-2',7'(4'H)-dione|-范德生物科技公司

Jacozine

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names：
(2S,3S,6'R,9a1'R,14a'R)-6'-hydroxy-3,6'-dimethyl-5'-methylene-5',6',9',9a1',11',13',14',14a'-octahydro-2'H-spiro[oxirane-2,3'-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine]-2',7'(4'H)-dione
CAS号：
5532-23-0
MDL Number：
MF(分子式)： C18H23NO6 MW(分子量)： 349.38
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Jacozine
英文别名	Jacozine;
CAS号	5532-23-0
Inchi	InChI=1S/C18H23NO6/c1-10-8-18(11(2)25-18)16(21)24-13-5-7-19-6-4-12(14(13)19)9-23-15(20)17(10,3)22/h4,11,13-14,22H,1,5-9H2,2-3H3/t11-,13+,14+,17+,18-/m0/s1
InchiKey	XCEPKQNOWNOSFH-CGPXFRKCSA-N
分子式 Formula	C18H23NO6
分子量 Molecular Weight	349.38
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Jacozine(CAS:5532-23-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Jacozine is an alkaloid found in ragwort.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Joosten L, Cheng D, Mulder PP, Vrieling K, van Veen JA, Klinkhamer PG. The genotype dependent presence of pyrrolizidine alkaloids as tertiary amine in Jacobaea vulgaris. Phytochemistry. 2011 Feb;72(2-3):214-22. doi: 10.1016/j.phytochem.2010.11.013. Epub 2010 Dec 13. PubMed PMID: 21159354.

[2]Li SL, Lin G, Fu PP, Chan CL, Li M, Jiang ZH, Zhao ZZ. Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang). Rapid Commun Mass Spectrom. 2008;22(4):591-602. doi: 10.1002/rcm.3398. PubMed PMID: 18220326.

[3] Tundis R, Loizzo MR, Statti GA, Passalacqua NG, Peruzzi L, Menichini F. Pyrrolizidine alkaloid profiles of the Senecio cineraria group (Asteraceae). Z Naturforsch C. 2007 Jul-Aug;62(7-8):467-72. PubMed PMID: 17913058.

[4] Christov VS, Mikhova BP, Evstatieva LN. Alkaloids from Senecio aquaticus. Fitoterapia. 2002 Apr;73(2):171-3. PubMed PMID: 11978435.

[5] Crews C, Startin JR, Clarke PA. Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC-MS. Food Addit Contam. 1997 Jul;14(5):419-28. PubMed PMID: 9328525.

6: Dueker SR, Lamé MW, Segall HJ. Hydrolysis rates of pyrrolizidine alkaloids derived from Senecio jacobaea. Arch Toxicol. 1995;69(10):725-8. PubMed PMID: 8572933.7: Goeger DE, Cheeke PR, Ramsdell HS, Nicholson SS, Buhler DR. Comparison of the toxicities of Senecio jacobaea, Senecio vulgaris and Senecio glabellus in rats. Toxicol Lett. 1983 Jan;15(1):19-23. PubMed PMID: 6836586.8: Deinzer ML, Thomson PA, Burgett DM, Isaacson DL. Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.) Science. 1977 Feb 4;195(4277):497-9. PubMed PMID: 835011.

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