35409-55-3|Hexaglutamate folate|(3S,8S,13S,18S,23S,28S)-1-(4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)amino)phenyl)-1,6,11,16,21,26-hexaoxo-2,7,12,17,22,27-hexaazatriacontane-3,8,13,18,23,28,30-heptacarboxylic acid|-范德生物科技公司

Hexaglutamate folate

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names：
(3S,8S,13S,18S,23S,28S)-1-(4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)amino)phenyl)-1,6,11,16,21,26-hexaoxo-2,7,12,17,22,27-hexaazatriacontane-3,8,13,18,23,28,30-heptacarboxylic acid
CAS号：
35409-55-3
MDL Number：
MF(分子式)： C44H54N12O21 MW(分子量)： 1086.97
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Hexaglutamate folate
英文别名	Hexaglutamate folate; Pteglu6;
CAS号	35409-55-3
Inchi	InChI=1S/C44H54N12O21/c45-44-55-35-34(37(65)56-44)48-21(18-47-35)17-46-20-3-1-19(2-4-20)36(64)54-27(43(76)77)9-15-32(61)52-25(41(72)73)7-13-30(59)50-23(39(68)69)5-11-28(57)49-22(38(66)67)6-12-29(58)51-24(40(70)71)8-14-31(60)53-26(42(74)75)10-16-33(62)63/h1-4,18,22-27,46H,5-17H2,(H,49,57)(H,50,59)(H,51,58)(H,52,61)(H,53,60)(H,54,64)(H,62,63)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H3,45,47,55,56,65)/t22-,23-,24-,25-,26-,27-/m0/s1
InchiKey	AIPNSTFJYXXLIP-QCOJBMJGSA-N
分子式 Formula	C44H54N12O21
分子量 Molecular Weight	1086.97
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Hexaglutamate folate(CAS:35409-55-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	is a naturally occurring form of folic acid. The bioavailability of dietary folate may be hampered by the need of the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans leads to anemia, neural tube defects and, possibly, chronic diseases such as cardiovascular disease, colon cancer, and neurocognitive dysfunction. Folate status is ascertained not only by the intake of folate but also by its bioavailability. Bioavailability is defined as the proportion of ingested folate that is absorbed and available for metabolic processes and storage. In humans, the bioavailability of folate from the diet is assumed to be {approx}50%, whereas the bioavailability of synthetic folic acid used in supplements and as a food fortificant is estimated to range from 76% to 97%. Patients with pernicious anemia in relapse and postgastrectomy macrocytic anemia cannot readily utilize for hematopoiesis a naturally occurring conjugate of pteroylglutamic acid although they respond promptly to administration of the free vitamin. This effect varies in different patients. Inability to utilize the conjugated vitamin appears to depend at least in part upon a conjugase-inhibiting substance present in natural sources of conjugate.
Application1
Application2
Application3

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安全声明
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备注

[1]Melse-Boonstra A, Verhoef P, West CE, van Rhijn JA, van Breemen RB, Lasaroms JJ, Garbis SD, Katan MB, Kok FJ. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am J Clin Nutr. 2006 Nov;84(5):1128-33. PubMed PMID: 17093166.

[2]Wei MM, Bailey LB, Toth JP, Gregory JF 3rd. Bioavailability for humans of deuterium-labeled monoglutamyl and polyglutamyl folates is affected by selected foods. J Nutr. 1996 Dec;126(12):3100-8. PubMed PMID: 9001380.

[3] Nelson EW, Crick WF, Cerda JJ, Wilder BJ, Streiff RR. The effect of diphenylhydantoin (phenytoin) on the sequential stages of intestinal folate absorption. Drug Nutr Interact. 1983;2(1):47-56. PubMed PMID: 6689591.

[4] Wong GK, Rao AV. Effects of dietary protein on the subacute toxicity of butylated hydroxytoluene (BHT) in rats. Drug Nutr Interact. 1983;2(1):57-68. PubMed PMID: 6678747.

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