101706-33-6|FR 900452|1-methyl-3-[1-[5-(methylsulfanylmethyl)-6-oxo-3-(2-oxocyclopent-3-en-1-ylidene)piperazin-2-yl]ethyl]-3H-indol-2-one|-范德生物科技公司

FR 900452

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names：
1-methyl-3-[1-[5-(methylsulfanylmethyl)-6-oxo-3-(2-oxocyclopent-3-en-1-ylidene)piperazin-2-yl]ethyl]-3H-indol-2-one
CAS号：
101706-33-6
MDL Number：
MF(分子式)： C22H25N3O3S MW(分子量)： 411.52
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	FR 900452
英文别名	FR 900452; FR900452; FR-900452
CAS号	101706-33-6
Inchi	InChI=1S/C22H25N3O3S/c1-12(18-13-7-4-5-9-16(13)25(2)22(18)28)19-20(14-8-6-10-17(14)26)23-15(11-29-3)21(27)24-19/h4-7,9-10,12,15,18-19,23H,8,11H2,1-3H3,(H,24,27)/b20-14-
InchiKey	UAPDNDKYPBHNQT-ZHZULCJRSA-N
分子式 Formula	C22H25N3O3S
分子量 Molecular Weight	411.52
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	FR 900452(CAS:101706-33-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	FR 900452 is a platelet activating factor antagonist from fermentatiion products of Streptomyces phaeofaciens.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Komaki H, Ichikawa N, Hosoyama A, Fujita N, Igarashi Y. Draft Genome Sequence of Streptomyces sp. TP-A0890, a Producer of FR-900452 and A-74863a. Genome Announc. 2015 Oct 15;3(5). pii: e01212-15. doi: 10.1128/genomeA.01212-15. PubMed PMID: 26472848; PubMed Central PMCID: PMC4611700.

[2]Okamoto M, Yoshida K, Nishikawa M, Ando T, Iwami M, Kohsaka M, Aoki H. FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1986 Feb;39(2):198-204. PubMed PMID: 3082838.

[3] Okamoto M, Yoshida K, Nishikawa M, Kohsaka M, Aoki H. Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. Thromb Res. 1986 Jun 1;42(5):661-71. PubMed PMID: 3754990.

[4] Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010.

[5] Okamoto M, Yoshida K, Nishikawa M, Hayashi K, Uchida I, Kohsaka M, Aoki H. Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. Chem Pharm Bull (Tokyo). 1986 Jul;34(7):3005-10. PubMed PMID: 3769104.

6: Hu W, McNicholl IK, Choy PC, Man RY. Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart. Br J Pharmacol. 1993 Oct;110(2):645-50. PubMed PMID: 8242237; PubMed Central PMCID: PMC2175904.7: Suzuki S, Nozawa R, Suzuki J, Kato K, Suzuki H, Sakurai K. [Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]. Nihon Jinzo Gakkai Shi. 1988 Aug;30(8):985-90. Japanese. PubMed PMID: 3244194.8: Hu W, Kinnaird AA, Man RY. Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 May;103(1):1097-102. PubMed PMID: 1652337; PubMed Central PMCID: PMC1908074.9: Man RY, Kinnaird AA. Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties. Br J Pharmacol. 1995 Nov;116(5):2359-64. PubMed PMID: 8581269; PubMed Central PMCID: PMC1909066.10: Chan WP, Levy JV. Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood. Prostaglandins. 1991 Oct;42(4):337-42. PubMed PMID: 1665568.1

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