40786-08-1|FPL-55712|7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]- 4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid sodium salt|-范德生物科技公司

FPL-55712

NMR下载 COA and HPLC MSDS下载
names：
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]- 4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid sodium salt
CAS号：
40786-08-1
MDL Number：
MF(分子式)： C27H29NaO9 MW(分子量)： 520.5098
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	FPL-55712
英文别名	FPL-55712; FPL55712; FPL 55712
CAS号	40786-08-1
SMILES	O=C(C1=CC(C2=CC=C(OCC(O)COC3=CC=C(C(C)=O)C(O)=C3CCC)C(CCC)=C2O1)=O)[O-].[Na+]
Inchi	InChI=1S/C27H30O9.Na/c1-4-6-19-22(10-8-17(15(3)28)25(19)31)34-13-16(29)14-35-23-11-9-18-21(30)12-24(27(32)33)36-26(18)20(23)7-5-2;/h8-12,16,29,31H,4-7,13-14H2,1-3H3,(H,32,33);/q;+1/p-1
InchiKey	ZDEVPOBNLIVGFA-UHFFFAOYSA-M
分子式 Formula	C27H29NaO9
分子量 Molecular Weight	520.5098
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	FPL-55712(CAS:40786-08-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	FPL-55712 is a CysLT1 leukotriene receptor antagonist.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Busch L, Miozza V, Sterin-Borda L, Borda E. Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis. Inflamm Res. 2009 Jul;58(7):423-30. doi: 10.1007/s00011-009-0008-8. Epub 2009 Apr 4. PubMed PMID: 19347252.

[2]Montuschi P. Leukotrienes, antileukotrienes and asthma. Mini Rev Med Chem. 2008 Jun;8(7):647-56. Review. Erratum in: Mini Rev Med Chem. 2008 Sep;8(10):1064. PubMed PMID: 18537720.

[3] Buccellati C, Fumagalli F, Viappiani S, Folco G. Leukotriene modifiers: novel therapeutic opportunities in asthma. Farmaco. 2002 Mar;57(3):235-42. Review. PubMed PMID: 11989802.

[4] Young RN. Discovery of montelukast: a once-a-day oral antagonist of leukotriene D4 for the treatment of chronic asthma. Prog Med Chem. 2001;38:249-77. Review. PubMed PMID: 11774796.

[5] Lai YL, Lee CF. Mediators and oxygen radicals in hyperpnea-induced airway constriction of guinea pigs. Lung. 2000;178(4):213-23. PubMed PMID: 10960556.

6: Hamanaka N, Nakai H. [Leukotriene D4 antagonists]. Tanpakushitsu Kakusan Koso. 2000 Apr;45(6 Suppl):967-72. Review. Japanese. PubMed PMID: 10771659.7: Lai YL, Lee SP. Mediators in hyperpnea-induced bronchoconstriction of guinea pigs. Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):597-602. PubMed PMID: 10598800.8: Nicosia S. Pharmacodynamic properties of leukotriene receptor antagonists. Monaldi Arch Chest Dis. 1999 Jun;54(3):242-6. Review. PubMed PMID: 10441979.9: Takami M, Tsukada W. In vitro effect of DP-1904, a novel anti-asthma agent, against antigen-induced constriction and TXB2 release from the isolated guinea-pig lung parenchymal tissue. Pharmacol Res. 1998 Aug;38(2):141-7. PubMed PMID: 9721602.10: Marcelle R. Leukotrienes antagonist-inhibitor and the bronchial response to inhaled antigen in actively sensitized guinea-pigs. Arch Physiol Biochem. 1998 Aug;105(4):358-64. PubMed PMID: 9711356.1

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