20633-93-6|Fortunellin|4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)-oxy)-5-hydroxy-2-(4-methoxyphenyl)-|-范德生物科技公司

Fortunellin

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names：
4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)-oxy)-5-hydroxy-2-(4-methoxyphenyl)-
CAS号：
20633-93-6
MDL Number：
MF(分子式)： C28H32O14 MW(分子量)： 592.55
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Fortunellin
英文别名	Fortunellin
CAS号	20633-93-6
SMILES	O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13
Inchi	InChI=1S/C28H32O14/c1-11-21(32)23(34)25(36)27(38-11)42-26-24(35)22(33)19(10-29)41-28(26)39-14-7-15(30)20-16(31)9-17(40-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-9,11,19,21-30,32-36H,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
InchiKey	MLWDGPFGTFOLRJ-CUVHLRMHSA-N
分子式 Formula	C28H32O14
分子量 Molecular Weight	592.55
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Fortunellin(CAS:20633-93-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Fortunellin is an antioxidant and anti-inflammatory agent that has been active against inflammation and oxidative stress that contribute to the progression of diabetic cardiomyopathy (DCM). Fortunellin may alleviate heart function and reduce inflammation and oxidative stress. The pro-inflammatory cytokines and the expression of p-IκB kinase α (IKKα), p-IκBα, and p-nuclear factor-κB (NF-κB) are inhibited by Fortunellin, while superoxide dismutase (SOD), catalase (CAT), heme oxygenase-1 (HO-1) and p-AMP-activated protein kinase (AMPK) were significantly enhanced. Fortunellin likely protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway in diabetic mice and cardiomyocytes with fructose treatment.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zhao C, Zhang Y, Liu H, Li P, Zhang H, Cheng G. Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation. Biochem Biophys Res Commun. 2017 Aug 19;490(2):552-559. doi: 10.1016/j.bbrc.2017.06.076. Epub 2017 Jun 15. PubMed PMID: 28624452.

[2]Lou SN, Lai YC, Hsu YS, Ho CT. Phenolic content, antioxidant activity and effective compounds of kumquat extracted by different solvents. Food Chem. 2016 Apr 15;197(Pt A):1-6. doi: 10.1016/j.foodchem.2015.10.096. Epub 2015 Oct 20. PubMed PMID: 26616917.

[3] Ilboudo O, Tapsoba I, Bonzi-Coulibaly YL, Gerbaux P. Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. Eur J Mass Spectrom (Chichester). 2012;18(5):465-73. doi: 10.1255/ejms.1199. PubMed PMID: 23221119.

[4] Lou SN, Lai YC, Huang JD, Ho CT, Ferng LH, Chang YC. Drying effect on flavonoid composition and antioxidant activity of immature kumquat. Food Chem. 2015 Mar 15;171:356-63. doi: 10.1016/j.foodchem.2014.08.119. Epub 2014 Sep 10. PubMed PMID: 25308680.

[5] Ge YB. [Chemical constituents of Fortunella margarita fruits]. Zhong Yao Cai. 2014 Mar;37(3):435-8. Chinese. PubMed PMID: 25174109.

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