70801-02-4|Flutroline|(+-)-8-Fluoro-alpha,5-bis(p-fluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido(4,3-b)indole-2-butanol|-范德生物科技公司

Flutroline

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names：
(+-)-8-Fluoro-alpha,5-bis(p-fluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido(4,3-b)indole-2-butanol
CAS号：
70801-02-4
MDL Number：
MF(分子式)： C27H25F3N2O MW(分子量)： 450.5
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Flutroline
英文别名	Flutroline; CP-36,584; Flutrolino; Flutrolinum; CP36,584; flutroline; flutroline, (+-)-isomer.
CAS号	70801-02-4
Inchi	InChI=1S/C27H25F3N2O/c28-19-5-3-18(4-6-19)27(33)2-1-14-31-15-13-26-24(17-31)23-16-21(30)9-12-25(23)32(26)22-10-7-20(29)8-11-22/h3-12,16,27,33H,1-2,13-15,17H2/t27-/m0/s1
InchiKey	OYGDOCFZQVGFIP-MHZLTWQESA-N
分子式 Formula	C27H25F3N2O
分子量 Molecular Weight	450.5
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Flutroline(CAS:70801-02-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Flutroline is a gamma-carboline antipsychotic agent.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Lehmann J, Knoch F, Jiang N. [Indoles. 10. Synthesis, structure and D2-affinity of beta-carboline analogs of flutroline]. Arch Pharm (Weinheim). 1993 Dec;326(12):947-5[1]German. PubMed PMID: 7907210.

[2]Sarges R, Howard HR, Donahue KM, Welch WM, Dominy BW, Weissman A, Koe BK, Bordner J. Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines. J Med Chem. 1986 Jan;29(1):8-19. Erratum in: J Med Chem 1986 May;29(5):876. PubMed PMID: 3941416.

[3] Falkner FC, Fouda HG, Mullins FG. A gas chromatographic/mass spectrometric assay for flutroline, a gamma-carboline antipsychotic agent, with direct derivatization on a moving needle injector. Biomed Mass Spectrom. 1984 Sep;11(9):482-5. PubMed PMID: 6150732.

[4] Kurland AA, Nagaraju A, Hanlon TE, Williams TG. The prolactin response to flutroline hydrochloride in schizophrenic patients. J Clin Pharmacol. 1983 Nov-Dec;23(11-12):505-16. PubMed PMID: 6141186.

[5] Kurland AA, Nagaraju A, Hanlon TE. Flutroline in the treatment of the schizophrenic patient. J Clin Pharmacol. 1982 Oct;22(10):441-9. PubMed PMID: 6129266.

6: Welch WM, Ewing FE, Harbert CA, Weissman A, Koe BK. 4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3 ,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic. J Med Chem. 1980 Aug;23(8):949-52. PubMed PMID: 6105220.7: Harbert CA, Plattner JJ, Welch WM, Weissman A, Koe BK. Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines. J Med Chem. 1980 Jun;23(6):635-43. PubMed PMID: 6104732.8: McEvoy JP, Berney S, Wilson WH, Ban TA, Guy W. A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia. Int Pharmacopsychiatry. 1980;15(5):318-24. PubMed PMID: 7021452.9: Fink M, Irwin P. EEG and behavioral profile of flutroline (CP-36,584), a novel antipsychotic drug. Psychopharmacology (Berl). 1980;72(1):67-71. PubMed PMID: 6110218.

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