25967-29-7|Flutoprazepam|2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-|-范德生物科技公司

Flutoprazepam

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names：
2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-
CAS号：
25967-29-7
MDL Number：
MF(分子式)： C19H16ClFN2O MW(分子量)： 342.8
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Flutoprazepam
英文别名	Flutoprazepam; Restar; Restas; Flutoprazepamum;
CAS号	25967-29-7
Inchi	InChI=1S/C19H16ClFN2O/c20-13-7-8-17-15(9-13)19(14-3-1-2-4-16(14)21)22-10-18(24)23(17)11-12-5-6-12/h1-4,7-9,12H,5-6,10-11H2
InchiKey	OFVXPDXXVSGEPX-UHFFFAOYSA-N
分子式 Formula	C19H16ClFN2O
分子量 Molecular Weight	342.8
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Flutoprazepam(CAS:25967-29-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Flutoprazepam is a benzodiazepine derivative extensively biotransformed by hepatic microsomal oxidation. This drug is unschedule in the USA but classified as a Schedule IV controlled substance in Canada.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Conti I, Sarati S, Caccia S. Propranolol does not alter flutoprazepam kinetics and metabolism in the rat. Eur J Drug Metab Pharmacokinet. 1991 Jan-Mar;16(1):53-8. PubMed PMID: 1936062.

[2]Barzaghi N, Leone L, Monteleone M, Tomasini G, Perucca E. Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects. Eur J Drug Metab Pharmacokinet. 1989 Oct-Dec;14(4):293-8. PubMed PMID: 2633923.

[3] Oki K, Sukamoto T, Ito K, Nose T. In vitro and ex vivo inhibition by flutoprazepam of [3H]flunitrazepam binding to mouse brain receptors. Arch Int Pharmacodyn Ther. 1984 Jun;269(2):180-6. PubMed PMID: 6148044.

[4] Moser L, Macciocchi A, Plum H, Bückmann. Effect of flutoprazepam on skills essential for driving motor vehicles. Arzneimittelforschung. 1990 May;40(5):533-5. PubMed PMID: 1974429.

[5] Kozaki A, Sakurai S, Awata N. [Metabolic fate of flutoprazepam (KB-509). IV. Pharmacokinetics of flutoprazepam-2-14C and desalkylflutoprazepam-2-14C in dog plasma]. Yakugaku Zasshi. 1982 Dec;102(12):1177-83. Japanese. PubMed PMID: 7182452.

6: Richards BL, Whittle SL, Buchbinder R. Muscle relaxants for pain management in rheumatoid arthritis. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008922. doi: 10.1002/14651858.CD008922.pub2. Review. PubMed PMID: 22258993.7: Ueki S, Sukamoto T, Watanabe S, Yamamoto T, Kataoka Y, Shibata S, Suwandi D, Shibata K, Takano M, Sato Y. [Behavioral effects of flutoprazepam (KB-509) and its metabolites]. Nihon Yakurigaku Zasshi. 1982 Jul;80(1):15-30. Japanese. PubMed PMID: 6890927.8: Fukinaga M, Ishizawa K, Kamei C. Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action. Pharmacology. 1998 Nov;57(5):233-41. PubMed PMID: 9742288.9: Sukamoto T, Aikawa K, Itoh K, Nose T. [Psycopharmacological and general pharmacological studies of 7-chloro-1-cyclopropylmethyl-1, 3-dihydro-5-(2-fluorophenyl)-2H-1, 4-benzodiazepin-2-one (KB-509) (author's transl)]. Nihon Yakurigaku Zasshi. 1980 Sep;76(6):447-68. Japanese. PubMed PMID: 7203280.10: Fukuda T, Itoh K, Nose T. [Antiulcerogenic action of 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin- 2-one (KB-509), a new benzodiazepine derivative]. Nihon Yakurigaku Zasshi. 1981 Mar;77(3):273-80. Japanese. PubMed PMID: 7052359.

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