88844-73-9|Flestolol sulfate|Benzoic acid, 2-fluoro-, 3-((2-((aminocarbonyl)amino)-1,1-dimethylethyl)amino)-2-hydroxypropyl ester, (+-)-, sulfate (11) (salt)|-范德生物科技公司

Flestolol sulfate

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names：
Benzoic acid, 2-fluoro-, 3-((2-((aminocarbonyl)amino)-1,1-dimethylethyl)amino)-2-hydroxypropyl ester, (+-)-, sulfate (11) (salt)
CAS号：
88844-73-9
MDL Number：
MF(分子式)： C15H24FN3O8S MW(分子量)： 425.43
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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FMK15328-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名	Flestolol sulfate
英文别名	Flestolol sulfate; ACC9089; ACC-9089; ACC 9089
CAS号	88844-73-9
Inchi	InChI=1S/C15H22FN3O4.H2O4S/c1-15(2,9-18-14(17)22)19-7-10(20)8-23-13(21)11-5-3-4-6-12(11)16;1-5(2,3)4/h3-6,10,19-20H,7-9H2,1-2H3,(H3,17,18,22);(H2,1,2,3,4)
InchiKey	QLCLNERFMKNCBZ-UHFFFAOYSA-N
分子式 Formula	C15H24FN3O8S
分子量 Molecular Weight	425.43
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Flestolol sulfate(CAS:88844-73-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Flestolol sulfate is an anti-adrenergic beta-receptor that produces several hemodynamic changes. These changes include a reduction in heart rate, rate pressure product, and increase in peripheral vascular resistance, as well as decrease in myocardial contractility. It is fast-acting with a short half-life.
Application1
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危险性	Warning
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安全声明
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备注

[1]Strom J, Josephson M, Frishman WH, Singh B, Heilbrunn S, Osterle S, Turlapaty P, Viray R, Coe J, Bell V, et al. Hemodynamic effects of flestolol, a titratable short-acting intravenous beta-adrenergic receptor blocker. J Clin Pharmacol. 1988 Mar;28(3):276-82. PubMed PMID: 2896204.

[2]Achari R, Drissel D, Hulse JD, Bell V, Turlapaty P, Laddu A, Matier WL. Pharmacokinetics and pharmacodynamics of flestolol, a new short-acting, beta-adrenergic receptor antagonist. J Clin Pharmacol. 1987 Jan;27(1):60-4. PubMed PMID: 2890664.

[3] Swerdlow CD, Peterson J, Liem LB. Effect of flestolol on ventricular rate during atrial fibrillation in Wolff-Parkinson-White syndrome. Am J Cardiol. 1988 Jul 1;62(1):78-82. PubMed PMID: 2898208.

[4] Swerdlow CD, Peterson J, Turlapaty P. Clinical electrophysiology of flestolol, a potent ultra short-acting beta blocker. Am Heart J. 1986 Jan;111(1):49-53. PubMed PMID: 2868646.

[5] Grohs JG, Fischer G, Raberger G. Effects of flestolol, an ultra-short acting beta-adrenoceptor antagonist, on hemodynamic changes produced by treadmill exercise or isoprenaline stimulation in conscious dogs. J Cardiovasc Pharmacol. 1990 Feb;15(2):175-81. PubMed PMID: 1689410.

6: Fischer G, Grohs JG, Raberger G. Verification of a canine model of transient exercise induced myocardial dysfunction: antianginal effects of flestolol, an ultra short acting beta adrenoceptor antagonist. Cardiovasc Res. 1990 Feb;24(2):115-20. PubMed PMID: 1970278.7: Murthy VS, Hwang TF, Rosen LB, Gorczynski RJ. Controlled beta-receptor blockade with flestolol: a novel ultrashort-acting beta-blocker. J Cardiovasc Pharmacol. 1987 Jan;9(1):72-8. PubMed PMID: 2434798.8: Reynolds RD, Brown BS. Antiarrhythmic activity of flestolol, a novel ultra-short-acting beta-adrenoceptor antagonist, in the dog. Eur J Pharmacol. 1986 Nov 12;131(1):55-66. PubMed PMID: 2880726.9: Achari R, Hulse JD, Drissel D, Matier WL. Pharmacokinetics of flestolol in man: preliminary data. Br J Clin Pharmacol. 1985 Dec;20(6):691-4. PubMed PMID: 2868745; PubMed Central PMCID: PMC1400830.10: Swerdlow C, Peterson J, Liem LB, Blake K, Franz MR, Laddu A. Electropharmacology of flestolol for supraventricular tachycardia without associated structural heart disease. Am J Cardiol. 1987 Nov 1;60(13):1055-60. PubMed PMID: 2890290.1

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