29177-84-2|Ethyl loflazepate|ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylate|-范德生物科技公司

Ethyl loflazepate

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names：
ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylate
CAS号：
29177-84-2
MDL Number：
MF(分子式)： C18H14ClFN2O3 MW(分子量)： 360.76
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Ethyl loflazepate
英文别名	Ethyl loflazepate; Loflazepato de etilo; CM 6912; CM-6912; CM6912; Ethylis loflazepas;
CAS号	29177-84-2
Inchi	InChI=1S/C18H14ClFN2O3/c1-2-25-18(24)16-17(23)21-14-8-7-10(19)9-12(14)15(22-16)11-5-3-4-6-13(11)20/h3-9,16H,2H2,1H3,(H,21,23)
InchiKey	CUCHJCMWNFEYOM-UHFFFAOYSA-N
分子式 Formula	C18H14ClFN2O3
分子量 Molecular Weight	360.76
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ethyl loflazepate(CAS:29177-84-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ethyl loflazepate is discontinued (DEA controlled substance). This product is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
Application1
Application2
Application3

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危险性	Warning
危险性警示
安全声明
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备注

[1]Kanemura H, Sano F, Sugita K, Aihara M. Effects of ethyl loflazepate on refractory epilepsy in children. J Child Neurol. 2011 Oct;26(10):1284-9. doi: 10.1177/0883073811405202. Epub 2011 May 18. PubMed PMID: 21596702.

[2]Fukami G, Hashimoto T, Shirayama Y, Hasegawa T, Watanabe H, Fujisaki M, Hashimoto K, Iyo M. Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects. Ann Gen Psychiatry. 2010 Nov 3;9:37. doi: 10.1186/1744-859X-9-37. PubMed PMID: 21047414; PubMed Central PMCID: PMC2991318.

[3] Ba BB, Iliadis A, Cano JP. Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites. Ann Biomed Eng. 1989;17(6):633-46. PubMed PMID: 2574017.

[4] Sakai Y, Namima M. Studies on the muscle relaxation effects of ethyl loflazepate (CM6912) and evaluation as an anti-anxiety drug. Jpn J Pharmacol. 1984 Nov;36(3):319-28. PubMed PMID: 6151605.

[5] Cano JP, Sumirtapura YC, Cautreels W, Sales Y. Analysis of the metabolites of ethyl loflazepate by gas chromatography with electron-capture detection. J Chromatogr. 1981 Dec 11;226(2):413-22. PubMed PMID: 6119320.

6: Chambon JP, Perio A, Demarne H, Hallot A, Dantzer R, Roncucci R, Bizière K. Ethyl loflazepate: a prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities. Arzneimittelforschung. 1985;35(10):1573-7. PubMed PMID: 2866771.7: Ba BB, Iliadis A, Durand A, Berger Y, Necciari J, Cano JP. Effect of renal failure on the pharmacokinetics of ethyl loflazepate (Victan) in man. Fundam Clin Pharmacol. 1989;3(1):11-7. PubMed PMID: 2714728.8: Sakai Y, Namima M. Inhibitory effect on 3H-diazepam binding and potentiating action on GABA of ethyl loflazepate, a new minor tranquilizer. Jpn J Pharmacol. 1985 Apr;37(4):373-9. PubMed PMID: 2861304.9: Ueki S, Watanabe S, Yamamoto T, Shibata S, Shibata K, Ohta H, Ikeda K, Kiyota Y, Sato Y. [Behavioral effects of ethyl loflazepate and its metabolites]. Nihon Yakurigaku Zasshi. 1983 Nov;82(5):395-409. Japanese. PubMed PMID: 6142848.10: Kuwahara H, Tanaka M, Isozaki H, Mizuki Y, Suetsugi M, Inanaga K. Analysis of sleep EEGs by the interval histogram method--validity of the baseline night as a control and the effect of ethyl loflazepate (CM6912). Kurume Med J. 1996;43(4):305-12. PubMed PMID: 9029900.1

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